This study aimed to investigate the various bioactive constituents of the leaves of two desert plants belonging to family Asteraceae Artemisia jaudica and Artemisia monosperma consumed in the Egyptian folk medicine.Nutritional value,antioxidant activity, antimicrobial activity, phytochemicals; total phenolics, flavanoids, saponins, alkaloids andterpenoids which have different therapeutic uses were studied. Proximate composition of the plants was determined following AOAC method. Phytochemical screening, antioxidant activity and antimicrobial spectrum of methanol and water extracts were performed using several assays according to the  standard procedures. Results revealed that the nutritional leaves of A. monosperma and A. jaudica are good source of energy, dietary fiber, proteins, carbohydrates and fats.The phytochemicals results revealed that the prepared extractshavegood antioxidant activity. The extracts showed good antimicrobial activity against gram positive bacteria, gram negative bacteria and one fungal strain. Conclusively, the dried leaves of A. monosperma and A. jaudicaare good source of health promoting constituents which can be used for therapeutic and nutritional purposes, therefore there is need for further studies on the active compounds of these xerophytic plants so as to maximize their medicinal and nutritional values.