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201676

Evaluation of antiurolithiatic and antioxidant activity of the Egyptian Pluchea dioscoridis L. leaves extracts in vitro

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Last updated: 25 Dec 2024

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Abstract

           Bioactive compounds in medicinal plants are believed to be an important in the folk of medicine. Many efforts have been done to discover the safe medical treatment instead of chemical drugs which have a harmful effect on the human body. In the present study the crude extracts of Pluchea dioscoridis were tested to evaluate their bioactive compounds (total phenolic and flavonoid compounds) and their effects as antiurolithiasis of human stones (calcium triphosphate (CTP), cholesterol and calcium oxalate monohydrate (COM) besides, their antioxidant activities. The measured total phenolic compounds content in the methanol, ethyl acetate, and water extracts of Pluchea dioscoridiswere found to be equal to 11.842, 9.047, and 8.126 mg/g, respectively. Also, the contents of the total flavonoid compounds (total phenol) were 19.018, 15.312, and 14.022mg/g for methanol, ethyl acetate, and aqueous extracts of P.dioscoridis, respectively. The results showed that all extracts of P. dioscoridis have a significant inhibitory effect on the dissolution of the three investigated types of formed stones (CTP, cholesterol, and COM). The inhibition effect was in the order methanol > ethyl acetate > water extract. Also, it was found that all extracts for P.dioscoridis were exhibited 2, 2, diphenyl-1-picryl hydrazil (DPPH) radical, reducing power, ABTS∙+ radical, Nitric oxide radical scavenging activity. Methanol extract of P. dioscoridis exhibited the highest scavenging activity compared to ethyl acetate and water extracts.     Refaat Ahmed Saber

DOI

10.21608/ajbs.2021.201676

Keywords

Pluchea dioscoridis, Antiurolithiatic, antioxidant, Flavonoids, Phenolic compounds

Authors

First Name

refaat

Last Name

saber

MiddleName

ahmed

Affiliation

Soil and Water department, faculty of Technology and development, zagazig university, zagazig. zagazig, Egypt.

Email

chem_refaat63@yahoo.com

City

hehia- sharkia

Orcid

0000-0002-5838-6693

Volume

17

Article Issue

1

Related Issue

21458

Issue Date

2021-12-01

Receive Date

2021-10-03

Publish Date

2021-12-01

Page Start

233

Page End

249

Print ISSN

1687-4870

Online ISSN

2314-5501

Article File

AJBS_Volume 17_Issue 1_Pages 233-249.pdf

PDF . 542.5kB

Link

https://ajbs.journals.ekb.eg/article_201676.html

Detail API

https://ajbs.journals.ekb.eg/service?article_code=201676

Order

17

Type

Original Article

Type Code

1,101

Publication Type

Journal

Publication Title

African Journal of Biological Sciences

Publication Link

https://ajbs.journals.ekb.eg/

MainTitle

Evaluation of antiurolithiatic and antioxidant activity of the Egyptian Pluchea dioscoridis L. leaves extracts in vitro

Details

Type

Article

Created At

22 Jan 2023