This study was undertaken to investigate the efficiency of partial replacement of soybean meal (SBM) by Jatropha curcas meal treated with lactobacillus acidophilus at rate of 1g/100kg. Four experimental diets were formulated, as iso nitrogenous (30.5 % crude protein) and isocaloric (4543.56Kcal/kg diet), containing 0, 25, 50 and 75% of treated Jatropha meal  (TJM) T1, T2, T3 and T4, respectively and fed to monosex Nile tilapia, (Oreochromis niloticus) fingerlings with average weight (30.43±1.14g/fish).Total of 60 fingerlings were random distributed in four treatments, triplicate groups each with five fish/ aquarium. The experiment period was lasted for 70 days. Growth performance, feed utilization and body compositions as well as the economic evaluation were monitored. The obtained data showed that, higher weight gain and the best feed conversion ratio (FCR), protein efficiency ratios (PER), protein productive value (PPV % ) and  energy utilization (EU%) recorded for fish fed diets (up to 50 %) of treated Jatropha meal were insignificantly different from those fed soybean meal.  It could be concluded that the SBM can be partial replaced with TJM  up to50 % of SBM without any  adverse effects on growth performance or feed utilization of Nile tilapia.