This work was carried out to evaluate the potential mutagenic effect of the two stored seeds protectant agents “Malathion 1% powder and Phosphine fumes^", commonly used in Egypt, to protect the stored beans from two storage Bruchids pests (Callosobruchus maculates F and C. chinensis L.) after six months of storing of Vicia faba seeds (Var. Giza 716) under treatment with (1, 2 & 4 times the effective concentrations) of each of the two agents. The evaluation took place on: germ cells (meiosis); some quantitative agronomic traits of F1&F2 generation plants and the changes in the storage protein banding pattern of M2 seeds, for each concentration comparing with concomitant negative control.
 The obtained results emphasized that: “Phosphine fumes" is the more potential mutagenic agent, while “Malathion 1% powder" was the least. So for the need of agriculture Malathion 1% powder can be safely used as seeds' protectant agent for storage if used in the recommended concentration.