This study was carried out during a period extending between March 2016 and February 2017. The aim of this work is to make a comparison between certain physico-chemical and biological parameters at three different water plants in El-Menofeyia province, Egypt. According to data of the physico-chemical parameters, the treated water at these treatment plants proved a remarkable enhancement as compared with raw one mainly with the values of TDS, Conductivity, Turbidity, Total alkalinity, Phosphates, Nitrates and Ammonia. Regarding biotic component, it was proved that both Total and Fecal coliform beside protozoans disappeared more or less completely at the end of the water treatment process in the present study. On the other hand, the protozoan organisms showed that the total protozons, sarcodines and ciliates' numerical densities achieved the highest densities during June 2016 in Meligue and Dalaton influent water, while those of Shobra-bass occurred on March for ciliates, October-November for flagellates and August for sarcodines. From the  practical and statistical point of views,  it could be possible to conclude that the direct filtration treatment process (Meligue) was the most effective method  to obtain better potable water followed by the river-bank filtration (Dalaton) then the compact water treatment plant at Shobra-bass.