This study aimed to determine the effects of sub-lethal concentrations of lead (PbCl2) on some oxidative stress in the African catfish Clarias gariepinus. Fishes were captured from Manzala Lake, Egypt. They were acclimatized and fed with commercial fish diet for one month before starting the experiment. Two experimental groups were exposed to two sub-lethal concentrations (10% and 30% of LC₅₀) of lead chloride, fishes from different experimental groups were sacrificed after 60 days of exposure. Oxidative stress enzymes such as GSH, CAT, SOD, and MDA were estimated. Group treated with Pb10 % showed significantly lower concentrations of GSH. On the other hand, Pb 30% group showed a significantly higher concentration of CAT, MDA and SOD.