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271836

IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA

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Last updated: 25 Dec 2024

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Abstract

The immuno-regulatory cytokine interleukin 10 (IL-10) is important in reducing the inflammatory response during H. pylori infection. The goal of our study was to explain how H.pylori infection affects mucosal IL-10 mRNA expression. This study included seventy-three patients suffering from gastroduodenal disorders admitted to Assiut University Hospitals, (35 (47.95%) were males, and 38 (52.05%) were females). Three antral biopsies were obtained from each patient during endoscopic examination. Two invasive tests (Rapid urease test (RUT) and polymerase chain reaction (PCR)) were performed for the detection of H. pylori infection in all participants. Real time PCR (RT-PCR) was performed for determination of IL-10 mRNA expression. Results of RUT and PCR indicated that 60.27% of patients were H. pylori infected. Our results showed that patients positive for H. pylori had significantly higher IL10 mRNA expression than H. pylori-negative patients. Finally, overexpression of IL‑10 during H. Pylori infection may be implicated in the downregulation of excessive immune response.
 

DOI

10.21608/bfsa.2022.271836

Keywords

H. pylori, interleukin‑10, Rapid urease test, and real time PCR

Authors

First Name

Ibrahim

Last Name

Amin

MiddleName

A.

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

abdelhadyibrahim@yahoo.com

City

-

Orcid

0000-0002-2915-2345

First Name

Mona

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

mona-a-hassan@hotmail.com

City

-

Orcid

-

First Name

Sherein

Last Name

Elgendy

MiddleName

G.

Affiliation

Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

shereinelgendy@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelmohsen

MiddleName

Shawkat.

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

shawkatamhed84@aun.edu.eg

City

-

Orcid

-

First Name

Mamdouh

Last Name

Ali

MiddleName

Yones

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Bahaa-Eldin

Last Name

Abdel-Raady

MiddleName

A.

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

vipdrbahaa67@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-05-24

Publish Date

2022-12-01

Page Start

1,175

Page End

1,185

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1175-1185.pdf

PDF . 840.7kB

Link

https://bpsa.journals.ekb.eg/article_271836.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271836

Order

271,836

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA

Details

Type

Article

Created At

22 Jan 2023