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EVALUATION OF PRESERVATIVE EFFECTIVENESS IN SOME EYE DROPS IN SYRIAN MARKET BY ANTIMICROBIAL EFFECTIVENESS TEST ACCORDING TO DIFFERENT PHARMACOPEIAS

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Last updated: 25 Dec 2024

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Abstract

Ophthalmic drops are subject to microbial contamination during use and storage by repeated opening of bottle when administrating individual doses, touching dropper-tip with infected eye/eyelid or contaminated hands, that why preservatives are added to eye drops packaged in multidose containers to prevent preparation spoilage and minimize hazards of ophthalmic infections ,especially in post-operative patients.
The aim of this study is to evaluate and compare the effectiveness of preservatives in three commercially marketed ophthalmic drops (timolol maleate solution 0.5%, polyvinyl alcohol solution 1.4%, and prednisolone acetate suspension 1%) in Syrian market by compendial antimicrobial effectiveness test which is not yet subject to international harmonization in different pharmacopeias.
The results showed that timolol maleate ophthalmic solution 0.5%, and polyvinyl alcohol ophthalmic solution 1.4% comply with different compendial acceptance criteria in antimicrobial effectiveness test(AET) , while prednisolone acetate ophthalmic suspension 1% didn't comply with any of compendial acceptance criteria.. There are many reasons can lead to preservative failure like adsorption of preservatives on plastic bottles and/or differences in formulation conditions of eye drops  (viscosity- increasing agents , surfactants, incompatibility between product's pH range and optimal pH range of preservative used).
 

DOI

10.21608/bfsa.2022.271828

Keywords

ophthalmic/eye drops, sterility, preservative effectiveness, microbial contamination, compendial test

Authors

First Name

Reem

Last Name

Rajab

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Baath University, Homs, Syria

Email

rmrajab@albaath-univ.edu.sy

City

-

Orcid

-

First Name

Youssef

Last Name

AlAhmad

MiddleName

-

Affiliation

Faculty of Pharmacy, Arab University for Science and Technology (AUST), Hama, Syria

Email

yousefalahmad@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-15

Publish Date

2022-12-01

Page Start

1,155

Page End

1,163

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1155-1163.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_271828.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271828

Order

271,828

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF PRESERVATIVE EFFECTIVENESS IN SOME EYE DROPS IN SYRIAN MARKET BY ANTIMICROBIAL EFFECTIVENESS TEST ACCORDING TO DIFFERENT PHARMACOPEIAS

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Article

Created At

22 Jan 2023