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271825

NANOPARTICLES BASED COMBINED ANTIMICROBIAL DRUG DELIVERY SYSTEM AS A SOLUTION FOR BACTERIAL RESISTANCE

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Last updated: 04 Jan 2025

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Abstract

The absence of novel antimicrobials is a main cause of the emergence of antibiotic resistance. Antimicrobial resistance has been evolved because of a variety of methods such as enzyme inactivation, reduced cell permeability, target mutation, changed target site/enzyme, and efflux pump overexpression. Using a combination of two antimicrobials drugs lead to an increase of the spectrum of antibiotics against multi drug resistance bacteria and a decrease in the emergence of resistant mutants. Despite of several advantages of using a combination of antibiotics, resistance can develop during treatment.  Encapsulation of antimicrobials within the nanoparticles was proven to reduce the antimicrobial resistance by increasing the intracellular bioavailability of antimicrobial drugs through decreasing the development of resistant mutants and inhibiting the efflux pump. In this review, we will summarize the antimicrobial resistance, use of combined therapy and the use of antimicrobials- loaded nanoparticles and their application in the future to fight multidrug resistant bacteria.
 

DOI

10.21608/bfsa.2022.271825

Keywords

Nanoparticles, Antimicrobial resistance, Antimicrobial combination, ciprofloxacin, Meropenem

Authors

First Name

Safy

Last Name

Hadiya

MiddleName

-

Affiliation

Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut 71515, Egypt

Email

ph.s.h.1989@gmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Ibrahem

MiddleName

A

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61511, Egypt

Email

reham.ali@mu.edu.eg

City

-

Orcid

Reham Ali Ibrahim

First Name

Rehab

Last Name

Abd El-Baky

MiddleName

M

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61511, Egypt -Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia 61511, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Elsabahy

MiddleName

-

Affiliation

School of Biotechnology, Badr University in Cairo, Badr City 11829, Egypt - Department of Chemistry, Texas A&M University, College Station, TX 77842, USA

Email

-

City

-

Orcid

-

First Name

Sherine

Last Name

Aly

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Assiut University

Email

aly71@windowslive.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-02-22

Publish Date

2022-12-01

Page Start

1,121

Page End

1,141

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1121-1141.pdf

PDF . 1.7MB

Link

https://bpsa.journals.ekb.eg/article_271825.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271825

Order

271,825

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NANOPARTICLES BASED COMBINED ANTIMICROBIAL DRUG DELIVERY SYSTEM AS A SOLUTION FOR BACTERIAL RESISTANCE

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Type

Article

Created At

22 Jan 2023