Beta
ManageSearchChatDiscover
271824

INTERFERON LAMBDA-3 AS A NEW CANDIDATE GENE INVOLVED IN THE PROGRESSION OF IDIOPATHIC PULMONARY FIBROSIS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial respiratory illness with an unknown origin, which leads to inevitably fatal outcomes in the majority of cases. The pro-inflammatory cytokine interferon lambda-3 (IFN-λ3) has been recently identified as a risk factor for the development of lung fibrosis in scleroderma patients. In this study, we examined the involvement of IFN-λ3 in IPF by utilizing the mouse model of BLM-induced pulmonary fibrosis. Our study identifies a remarkable overexpression in the mRNA of IFNL3, and a positive significant correlation between the IFNL3 mRNA levels and the various pro-inflammatory cytokines for instance NF-kB, TNF-α, IL-1β and TGF-β throughout the three-weeks study. These findings have proven the impact of IFNL3 on BLM-induced pulmonary fibrosis occurrence and progression. Moreover, the data suggest that the pro-inflammatory and pro-fibrotic capacities of IFNL3 may be provoked by additional pro-inflammatory cytokines NF-kB, TNF-α, IL-1β, and TGF-β. In conclusion, IFN-λ3 looks like a promising target in the therapeutic development of new drug candidates for pulmonary fibrosis.
 

DOI

10.21608/bfsa.2022.271824

Keywords

Idiopathic pulmonary fibrosis, interferon lambda-3

Authors

First Name

Eman

Last Name

Hamdi

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

dinataha201693@gmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Abdelrehim

MiddleName

B.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

-

City

-

Orcid

-

First Name

Aliaa

Last Name

Higazi

MiddleName

-

Affiliation

Department of Clinical pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt

Email

ggg@nn.com

City

-

Orcid

-

First Name

Abo Bakr

Last Name

Ahmed

MiddleName

F.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Thabet

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

Email

khaled_sabet@mu.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-08-17

Publish Date

2022-12-01

Page Start

1,109

Page End

1,119

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1109-1119.pdf

PDF . 1.2MB

Link

https://bpsa.journals.ekb.eg/article_271824.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271824

Order

271,824

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERFERON LAMBDA-3 AS A NEW CANDIDATE GENE INVOLVED IN THE PROGRESSION OF IDIOPATHIC PULMONARY FIBROSIS

Details

Type

Article

Created At

22 Jan 2023