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EVALUATION OF ADIPOSITY PHENOTYPES: LIPID ACCUMULATION PRODUCT INDEX, VISCERAL ADIPOSE INDEX AND BODY ROUNDNESS INDEX AS PREDICTOR MARKERS FOR METABOLIC SYNDROME DEVELOPMENT IN T

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Last updated: 25 Dec 2024

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Abstract

Visceral obesity is strongly associated with Metabolic syndrome (MetS) and increases the risk of cardiovascular disease in type II diabetes mellitus (T2DM). We aimed in this study to determine the best discriminator of obesity indexes to predict the occurrence of MetS in T2DM patients. The present study was conducted on 129 T2DM patients (Mets+: 70.54% & MetS-: 29.45%) during the period from 2020 to 2021. MetS+ patients have higher HbA1C, TG, and obesity indexes (BMI, WC, BF%, BRI, VAI, LAP) compared with MetS- group with a lower HDL-cholesterol in the MetS+ group. The average of  BF%, VAI, and LAP increased with increasing the number of MetS components according to NCEP-ATPIII criteria. In addition, the optimal cutoff points for obesity indexes were determined. Therefore, LAP with cutoff: 46.48 (AUC: 0.774, sensitivity: 80.2%, and specificity: 62.5%), VAI with cutoff: 1.73 (AUC: 0.668, sensitivity: 71.4%, and specificity: 54.2% ), and BRI with cutoff: 5.22 (AUC: 0.774, sensitivity: 82.4%, and specificity: 58.3%) seemed to be as useful indexes  in MetS prediction among T2DM patients. 
 

DOI

10.21608/bfsa.2022.271823

Keywords

Obesity, lap, VAI, RBI, and MetS

Authors

First Name

Remal

Last Name

Asaad

MiddleName

Abdulaziz

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

rimalasaad@tishreen.edu.sy

City

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Orcid

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Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-06

Publish Date

2022-12-01

Page Start

1,097

Page End

1,107

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1097-1107.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_271823.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271823

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271,823

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EVALUATION OF ADIPOSITY PHENOTYPES: LIPID ACCUMULATION PRODUCT INDEX, VISCERAL ADIPOSE INDEX AND BODY ROUNDNESS INDEX AS PREDICTOR MARKERS FOR METABOLIC SYNDROME DEVELOPMENT IN TYPE 2 DIABETES MELLITUS

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Type

Article

Created At

22 Jan 2023