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PHARMACOLOGICAL EVALUATION OF NOOTROPIC AND NEUROPROTECTIVE ACTIVITY OF SESBANIA GRANDIFLORA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC MODEL OF RATS

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Last updated: 25 Dec 2024

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Abstract

Background: Diabetes Mellitus (DM) is a multifactorial disorder and is frequently correlated with chronic problems associated with various major organs. In recent times, there has been some correlations reported about the neurological complications of DM, such as cognitive impairment, vascular dementia, stroke, or depression. and observed that the brain tissue of the diabetic patients with hyperglycemia have shown injury at various locations with a varied profile of micro and macrostructural changes, which leads to the neurodegeneration, neuro-vascular deterioration, neuro-inflammation, and progressive cognition decline. Aim: The current study assesses memory enhancing activity of Sesbania grandiflora (SG) extracts in streptozotocin (STZ)-induced diabetic model in rat. Methods: The extracts (petroleum ether, ethyl acetate and methanol) were analyzed for acute toxicity and later its neuroprotective and memory enhancing activity in the selected rat model. STZ (55 mg/kg) injection was administered intraperitoneally to the animals to induce memory impairment. SG extracts were administered for 70 days after confirming STZ-induced dementia to detect its beneficial effect. To know the memory function the animals were subjected to Y-maze and Morris water maze test. After the tests, the animals were sacrificed and performed cholinergic function and oxidative stress with the brain tissue. Results: It was observed that STZ caused significant memory impairment, which was significantly reversed by methanolic extract with 100 and 200 mg/kg. It was found that the cholinergic dysfunction, rise in lipid peroxidation levels were significantly (p<0.001) reduced. In the diabetic induced group, it was identified that there was a radical reduction of glutathione, superoxide dismutase, and catalase activities than the control group animals. Conclusion: The current investigation established that SG leaf extracts improve the memory by enhancing the cholinergic transmission and reducing the oxidative stress in the brain of diabetic rats.

DOI

10.21608/bfsa.2022.271820

Keywords

diabetes, Dementia, cholinergic dysfunction, oxidative stress and Sesbania grandiflora

Authors

First Name

Jagadeeshwar

Last Name

Kolguri

MiddleName

-

Affiliation

K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502

Email

jagadeeshwarkolguri@gmail.com

City

-

Orcid

-

First Name

Subhakara

Last Name

Rapaka

MiddleName

Raju

Affiliation

K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502

Email

-

City

-

Orcid

-

First Name

Rajasekhar

Last Name

Alavala

MiddleName

Reddy

Affiliation

K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502 -Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai- 400056, India

Email

-

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-

Orcid

-

First Name

Koteswara

Last Name

GSN

MiddleName

Rao

Affiliation

K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522502

Email

-

City

-

Orcid

-

First Name

Shireesha

Last Name

Boyapati

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, Telangana, India-503322

Email

sirimedchem@gmail.com

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-

Orcid

-

First Name

Raghavendra

Last Name

Gunda

MiddleName

Kumar

Affiliation

Department of Pharmaceutical Sciences, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, India-522213

Email

drrkgpharmacy@gmail.com

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-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-29

Publish Date

2022-12-01

Page Start

1,063

Page End

1,076

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1063-1076.pdf

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https://bpsa.journals.ekb.eg/article_271820.html

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https://bpsa.journals.ekb.eg/service?article_code=271820

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271,820

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHARMACOLOGICAL EVALUATION OF NOOTROPIC AND NEUROPROTECTIVE ACTIVITY OF SESBANIA GRANDIFLORA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC MODEL OF RATS

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Article

Created At

22 Jan 2023