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271790

PREVALENCE OF ALLOIMMUNIZATION AGAINST RED BLOOD CELLS ANTIGENS IN SICKLE CELL DISEASE PATIENTS IN LATAKIA, SYRIA

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Last updated: 25 Dec 2024

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Abstract

Sickle cell disease (SCD) is one of the most common inherited hemoglobin disorders in most parts of the world, including Syria. Red blood cells transfusion is a supportive procedure for patients with SCD. However, repeated blood transfusion is not risk-free; one major complication is RBCs alloimmunization; which is the focus of this study. Our objective was to estimate the prevalence of alloimmunization against RBCs antigens in multi-transfused SCD patients in the coastal city of Latakia, Syria, and to identify the involved alloantibodies. The factors that might affect RBC alloimmunization in these patients will also be studied. A multicenter study was carried on 100 SCD patients who previously received blood transfusions, and medical records of these patients were consulted. Antibody screening and identification were done using indirect antiglobulin test (IAT) at 37˚C in gel cards. Extended antigens phenotyping, autocontrols, and direct Coombs test (DAT) were also performed. In this first study in our region, we found that 10% of SCD patients developed clinically significant alloantibodies. None of the patients enrolled in our study had autoantibodies. Of 10 cases of alloimmunization, the alloantibodies we identified were: anti-c (3/10), anti-K alone (2/10), anti-E (1/10), anti-Fya (1/10), anti-D alone (1/10), anti-C with anti-D (1/10), anti-C with anti-K (1/10). Matching for Rh and Kell antigens will significantly decrease alloimmunization rate, since it may prevent the development around 90% of RBCs alloantibodies in a Syrian population of multi-transfused SCD patients.
 

DOI

10.21608/bfsa.2022.271790

Keywords

SCD, alloimmunization, antibody screening, transfusion

Authors

First Name

Saraa

Last Name

Baddour

MiddleName

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Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Latakia, Syria

Email

saraawbaddour@gmail.com

City

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Orcid

-

First Name

Mohamad

Last Name

AWAMA

MiddleName

Ayman

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Latakia, Syria

Email

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City

-

Orcid

-

First Name

Suzanne

Last Name

Alshemali

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Latakia, Syria

Email

-

City

-

Orcid

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Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-02-06

Publish Date

2022-12-01

Page Start

1,043

Page End

1,050

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1043-1050.pdf

PDF . 889.4kB

Link

https://bpsa.journals.ekb.eg/article_271790.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271790

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271,790

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREVALENCE OF ALLOIMMUNIZATION AGAINST RED BLOOD CELLS ANTIGENS IN SICKLE CELL DISEASE PATIENTS IN LATAKIA, SYRIA

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Article

Created At

22 Jan 2023