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271787

THE POTENTIAL MODULATING IMPACT OF THE DIPEPTIDYL PEPTIDASE-4 (DPP-4) INHIBITOR, SITAGLIPTIN ON STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC NEPHROPATHY IN RATS

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Last updated: 04 Jan 2025

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Abstract

The main risk factor for the onset and development of diabetic nephropathy (DN) is hyperglycemia. Kidney end-stage disease is brought on by DN, a significant microvascular consequence of diabetes. In this study, we evaluated the renoprotective potential of sitagliptin in a rat model of streptozotocin-nicotinamide-induced DN. Following the intraperitoneal treatment of rats with 110 mg/kg nicotinamide followed 15 min by 60 mg/kg streptozotocin, DN manifested in rats after 8 weeks. Fasting blood glucose, postprandial blood glucose, HbA1c, serum urea and creatinine, and urine albumin levels were assessed in control, DN, and DN rats treated with sitagliptin. Additionally, paraffin-embedded kidney segment histopathological assessment was carried out. The increased levels of fasting, postprandial blood glucose, and HbA1c were decreased with sitagliptin. Sitagliptin restored the changes in kidney structure and function brought on by DN. The findings suggest that sitagliptin could prevent DN by stringent glycemic management, restoring the kidneys' declining function and protecting their structure.
 

DOI

10.21608/bfsa.2022.271787

Keywords

streptozotocin, diabetic nephropathy, Sitagliptin, Kidney function and structure

Authors

First Name

Ahmed

Last Name

Abdel-Zaher

MiddleName

O.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Abd-Allah

MiddleName

G.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt

Email

marwagamalabdallah@gmail.com

City

-

Orcid

-

First Name

Ghada

Last Name

Mohammad

MiddleName

H.

Affiliation

Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt

Email

ghada.hosny1984@yahoo.com

City

-

Orcid

-

First Name

Rania

Last Name

Abdel-Emam

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

dr_raniamonem@aun.edu.eg

City

-

Orcid

0000-0003-2772-9566

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-21

Publish Date

2022-12-01

Page Start

1,013

Page End

1,026

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1013-1026.pdf

PDF . 1.0MB

Link

https://bpsa.journals.ekb.eg/article_271787.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271787

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271,787

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE POTENTIAL MODULATING IMPACT OF THE DIPEPTIDYL PEPTIDASE-4 (DPP-4) INHIBITOR, SITAGLIPTIN ON STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC NEPHROPATHY IN RATS

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Article

Created At

22 Jan 2023