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271786

EFFICACY OF OLMESARTAN, IRBESARTAN AND TELMISARTAN AGAINST ACUTE INDOMETHACIN-INDUCED GASTRIC ULCERS IN MICE

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Last updated: 04 Jan 2025

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Abstract

Recent studies have determined detrimental effects of angiotensin-II in gastric mucosa. This study aims to investigate the gastroprotective role of some Angiotensin-II receptor blockers (ARBs): olmesartan, irbesartan and telmisartan on indomethacin-induced gastric ulcers in mice. Also, it provides a new comparison to know if the agonist action of peroxisome proliferator-activated receptor gamma (PPAR-γ) involves in protecting gastric mucosa; if found. Animals were divided into six groups (n= 9 in each); group 1 (normal control), group 2 (non-pretreated, induced-ulcer), group 3 (olmesartan 8.2 mg/kg), group 4 (irbesartan 61.5 mg/kg), group 5 (telmisartan 16.4 mg/kg), group 6 (ranitidine 61.5 mg/kg). Drugs were given orally for 15 days; then gastric ulcers were induced by a single oral dose of indomethacin (250 mg/kg). Histological findings showed that these members of ARBs decreased the depth of ulcers but without significant difference between them. Their gastroprotective effects were not comparable to ranitidine effect. We need further researches, and recommend studying the effect of ARBs in combination with anti-ulcer drugs.
 
 

DOI

10.21608/bfsa.2022.271786

Keywords

Angiotensin-II, gastroprotective, ARBs, PPAR- γ, gastric ulcers, Indomethacin

Authors

First Name

Sara

Last Name

Khallouf

MiddleName

-

Affiliation

Pharmacology & Toxicology Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

sara.khallouf@tishreen.edu.sy

City

-

Orcid

-

First Name

Rana

Last Name

Makhous

MiddleName

-

Affiliation

Pharmacology & Toxicology Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

ranamakhous@gmail.com

City

-

Orcid

-

First Name

Rana

Last Name

Issa

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria

Email

ranissa@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-06-01

Publish Date

2022-12-01

Page Start

1,005

Page End

1,012

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 1005-1012.pdf

PDF . 963.9kB

Link

https://bpsa.journals.ekb.eg/article_271786.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271786

Order

271,786

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFICACY OF OLMESARTAN, IRBESARTAN AND TELMISARTAN AGAINST ACUTE INDOMETHACIN-INDUCED GASTRIC ULCERS IN MICE

Details

Type

Article

Created At

22 Jan 2023