Beta
ManageSearchChatDiscover
271784

DEXAMETHASONE-INDUCED METABOLIC SYNDROME: RE-EVALUATION OF AN UNDERESTIMATED EXPERIMENTAL MODEL

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Dexamethasone is a fluorinated steroid and a synthetic member of glucocorticoids. It is an approved medication for inflammatory and allergic disorders. Also, it is clinically used in high doses to manage pain associated with metastatic osteolytic lesions. Furthermore, it has a wide array of side effects, particularly at high doses and after prolonged consumption, like; hypertension, hyperglycemia, and dyslipidemia. It is a promising tool for studying the underlying mechanisms of metabolic syndrome and insulin resistance. This review article discusses metabolic syndrome and insulin signaling. In addition, this review article will discuss metabolic-dexamethasone effects on the skeletal muscle, liver, adipose tissue, pancreas, brain, and the cardiovascular system, its underlying mechanisms of action, and the benefits of use, in comparison to the other dietary and chemical models of insulin resistance and type 2 diabetes, to identify new potential pharmacological treatments of the metabolic syndrome and its related complications.
 

DOI

10.21608/bfsa.2022.271784

Keywords

Dexamethasone · Diabetes · Metabolic syndrome · Animal model

Authors

First Name

Mohamed

Last Name

Askar

MiddleName

M. M.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University Egypt

Email

m.askar22@pharmacy.zu.edu.eg

City

-

Orcid

0000-0002-1239-1710

First Name

Islam

Last Name

E-H Ibrahim

MiddleName

A. A.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Mahmoud

MiddleName

F.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University Egypt

Email

mfabdelaziz@zu.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-23

Publish Date

2022-12-01

Page Start

989

Page End

1,004

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 989-1004.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_271784.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271784

Order

271,784

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DEXAMETHASONE-INDUCED METABOLIC SYNDROME: RE-EVALUATION OF AN UNDERESTIMATED EXPERIMENTAL MODEL

Details

Type

Article

Created At

22 Jan 2023