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271778

POTENTIAL PROTECTIVE EFFECT OF METFORMIN AND L-CARNITINE IN RAT MODEL OF CARBOPLATIN-INDUCED MYELOSUPPRESSION, COMPARATIVE STUDY

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Last updated: 25 Dec 2024

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Abstract

Background: Carboplatin (CP), a well-known second-generation platinum compound, is effective against various malignancies including ovarian, lung, neck, breast, cervix and bladder cancer. However, myelosuppression is the most overwhelming toxic effect which results in leucopenia, thrombocytopenia and anemia. L-Carnitine (LCR) is a well-known antioxidant, cardioprotective, neuroprotective, and immunostimulant natural chemical compound. Metformin (MF) is a well-known drug approved for type 2 DM treatment. The aim of this work was to compare the potential protective effect of metformin and L-carnitine in a rat model of CP-induced myelosuppression. Methods and results: This study was performed on 40 adult male albino rats which were divided into four groups: control group, Carboplatin (CP) group, metformin (MF+CP) group and L-Carnitine (LCR+CP) group. Serum was used for measurement of TNF-α alpha, malondialdehyde (MDA), glutathione peroxidase (Gpx), glutathione reductase, catalase and superoxide dismutase (SOD) levels. Histopathological and immunohistochemical changes analyses were done in bone marrow. Carboplatin group showed redox status imbalance which was reversed by metformin and l-carnitine treatment corrected redox status balance. RBCs, WBCs and platelets counts were decreased in carboplatin treated group. Metformin and l-carnitine increased RBCs, WBCs and platelets counts significantly. TGF-β1 and caspase 3 expression were high in carboplatin treated group. Metformin and l-carnitine treatment significantly decreased their expression. Conclusions: Metformin and L-Carnitine have a possible protective role in myelosuppression induced by carboplatin and this effect is more potent with LCR treatment so we could recommend using L-Carnitine during Carboplatin treatment to prevent developing myelosuppression.

DOI

10.21608/bfsa.2022.271778

Keywords

Carboplatin, Myelosuppression, Metformin, L-carnitine, TGF-β1, Caspase 3

Authors

First Name

Rania

Last Name

Shalaby

MiddleName

H.

Affiliation

Pharmacology Department, Faculty of Medicine, Tanta University

Email

rania.shalabi@med.tanta.edu.eg

City

-

Orcid

-

First Name

Fatma

Last Name

Ibrahim

MiddleName

MKh

Affiliation

Pathology Department, Faculty of Medicine, Tanta University

Email

fatma.ibrahim@med.tanta.edu.eg

City

-

Orcid

-

First Name

Sarah

Last Name

Ibrahim

MiddleName

-

Affiliation

Anatomy Department, Faculty of Medicine, Tanta University

Email

sara.ibrahim@med.tanta.edu.eg

City

-

Orcid

-

First Name

Nadia

Last Name

helal

MiddleName

E.

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University

Email

nadia.helal@med.tanta.edu.eg

City

-

Orcid

-

First Name

Dina

Last Name

El-Guindy

MiddleName

M.

Affiliation

Pathology Department, Faculty of Medicine, Tanta University

Email

dina-elguindy@hotmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Eltabaa

MiddleName

F.

Affiliation

Physiology Department, Faculty of Medicine, Tanta University

Email

eman.eltabaa@med.tanta.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Safa

MiddleName

A.

Affiliation

Internal Medicine Department, Faculty of Medicine, Tanta University

Email

mohamed.safa@med.tanta.edu.eg

City

-

Orcid

-

First Name

Hanem

Last Name

Rabah

MiddleName

Mohamed

Affiliation

Biochemistry Department, Faculty of Medicine, Tanta University

Email

hanem.rabah@med.tanta.edu.eg

City

-

Orcid

-

First Name

Norhan

Last Name

AbuoHashish

MiddleName

Ahmed

Affiliation

Pharmacology Department, Faculty of Medicine, Tanta University

Email

nourhan.abohashesh@med.tanta.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-18

Publish Date

2022-12-01

Page Start

975

Page End

988

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 975-988.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_271778.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271778

Order

271,778

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

POTENTIAL PROTECTIVE EFFECT OF METFORMIN AND L-CARNITINE IN RAT MODEL OF CARBOPLATIN-INDUCED MYELOSUPPRESSION, COMPARATIVE STUDY

Details

Type

Article

Created At

22 Jan 2023