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LETROZOLE SUPPRESSES HEPATIC OXIDATIVE STRESS AND AMELIORATES LIPID ACCUMULATION IN FRUCTOSE-EXPOSED WISTER RATS

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Last updated: 25 Dec 2024

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Abstract

An increase in sugar intake, especially fructose or fructose-containing sweeteners,  poses a serious public health challenge globally. Unlike glucose, fructose metabolism results in generation of oxidative stress, which promotes hepatic lipid accumulation and consequently increases the risk of non-alcoholic fatty liver disease (NAFLD). Chronic administration of letrozole has been previously reported to decrease lipid peroxidation and increase antioxidants but its effect on fructose-induced lipid accumulation has not been investigated. Thus, the present study sought to investigate the ameliorative effect of letrozole on hepatic oxidative stress and lipid accumulation in high fructose-taking Wister rats. After 3-week of exposure, our results reveal that fructose intake increased hepatic total cholesterol (p< 0.01), triglycerides (p< 0.001) and free fatty acid (p< 0.001). Similarly, fructose increased hepatic malondialdehyde (MDA) (p< 0.001 vs. control) and decreased catalase and superoxide dismutase activities (p< 0.001 and p < 0.05 vs. control, respectively). Furthermore, our data show that high fructose intake elevated levels of uric acid and xanthine oxidase activity in the liver (p< 0.001 vs. control). However, letrozole treatment attenuated the hepatic lipid accumulation, reduced MDA level, and suppressed uric acid biosynthesis in high fructose-taking rats. Conclusively, this study has demonstrated that high fructose intake induces hepatic uric acid synthesis, generating oxidative stress and promoting hepatic lipid accumulation in male Wister rats, while administration of letrozole attenuates the fructose effects. Our findings, therefore, suggest the efficacy of letrozole in attenuating hepatic lipid accumulation, hence, lowering the risk of NAFLD associated with excessive fructose intake.
 

DOI

10.21608/bfsa.2022.271777

Keywords

Fructose, Letrozole, hepatic lipid, Oxidative Stress, NAFLD

Authors

First Name

Adam

Last Name

Abdulkareem

MiddleName

Olaitan

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria -HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria -Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

Email

abdulkareem.ao@unilorin.edu.ng

City

-

Orcid

0000-0003-4850-5078

First Name

Emmanuel

Last Name

Abe

MiddleName

Olusegun

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

-

City

-

Orcid

-

First Name

Oluwafemi

Last Name

Omilana

MiddleName

Ololade

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria

Email

abdulkareem.cdri20j@acsir.res.in

City

-

Orcid

-

First Name

Lawrence

Last Name

Olatunji

MiddleName

Aderemi

Affiliation

HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria-Cardiovascular Research Unit, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria

Email

tunjilaw@unilorin.edu.ng

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-09

Publish Date

2022-12-01

Page Start

967

Page End

974

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 967-974.pdf

PDF . 737.2kB

Link

https://bpsa.journals.ekb.eg/article_271777.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271777

Order

271,777

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

LETROZOLE SUPPRESSES HEPATIC OXIDATIVE STRESS AND AMELIORATES LIPID ACCUMULATION IN FRUCTOSE-EXPOSED WISTER RATS

Details

Type

Article

Created At

22 Jan 2023