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271776

ASSESSMENT OF GENITAL AND URINARY TRACT INFECTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH DAPAGLIFLOZIN

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Last updated: 25 Dec 2024

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Abstract

Several studies have shown that pharmacologically induced glucosuria with dapagliflozin increases the risk of developing urinary and genital tract infections (UTIs). The aim of this study is to assess the incidence of urinary and genital infections and to investigate risk factors in T2DM patients treated with dapagliflozin 5 and 10 mg. The study included 108 patients with type 2 diabetes, aged between 40-70 years, randomly selected from the outpatient of the Endocrinology Department at Tishreen University Hospital in Syria. 52 patients received once daily dapagliflozin (5 or 10 mg) as add-on therapy to oral antihyperglycemic drugs, and 56 patients treated with antihyperglycemic agents for 24 weeks. We compared patients with well-controlled diabetes to deny the effect of HbA1c on the incidence of urinary and genital infections.
We observed that treatment with dapagliflozin is associated with an increased risk of developing genital infections. There was no statistically significant increase in the incidence of urinary infections in patients treated with dapagliflozin. We identified gender and a previous history of genital infection as risk factors for genital infection. Long-term studies are still needed to determine association of dapagliflozin with an increased risk of UTIs.
 

DOI

10.21608/bfsa.2022.271776

Keywords

Type 2 diabetes mellitus, Dapagliflozin, Urinary Tract infections, Genital infections, risk factors

Authors

First Name

Hiba

Last Name

Mayhoub

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

hibamay693@yahoo.com

City

-

Orcid

-

First Name

Arige

Last Name

BouBou

MiddleName

-

Affiliation

Department of Internal Medicine (Endocrinology), Faculty of Medicine, Tishreen University, Lattakia, Syria

Email

arigeboubou@yahoo.fr

City

-

Orcid

-

First Name

Nisrin

Last Name

Kaddar

MiddleName

-

Affiliation

Department of Pharmaceutics and Pharmaceutical Technology، Faculty of Pharmacy, Tishreen University, Lattakia, Syria

Email

nkaddar@yahoo.fr

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-07

Publish Date

2022-12-01

Page Start

953

Page End

965

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 953-965.pdf

PDF . 868.0kB

Link

https://bpsa.journals.ekb.eg/article_271776.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271776

Order

271,776

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSESSMENT OF GENITAL AND URINARY TRACT INFECTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH DAPAGLIFLOZIN

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Type

Article

Created At

22 Jan 2023