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271773

COMBINED ORAL CONTRACEPTIVE (ETHINYLESTRADIOL/ LEVONORGESTREL) ALLEVIATES LIPID AND LACTATE ALTERATIONS IN PLASMODIUM BERGHEI-INFECTED MICE

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Last updated: 25 Dec 2024

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Abstract

Despite the common use of combined oral contraceptive (COC) as a childbirth control pill, there is no sufficient information on the effect of COC in malaria. Hence, we aimed at investigating the effect of COC on parasite growth and the associated risk of metabolic disorder in Plasmodium berghei-infected mice. Twenty female mice were randomly allotted into four groups (n= 5/group): uninfected, infected (inoculated with P. berghei), COC (1.0 μg ethinylestradiol and 5.0 μg levonorgestrel, p.o/day, without infection) and infected + COC. Percentage parasitaemia was recorded weekly. At the end of 21-day exposure, the mice were sacrificed, while blood and liver were collected for biochemical analyses. Our data showed progressive increase in parasitaemia in P. berghei-infected mice. Our findings also revealed that P. berghei infection did not affect serum levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and total cholesterol (TC). It, however, elevated serum malondialdehyde (MDA), serum and liver triglycerides and liver TC. Elevations of serum and liver free fatty acid and lactate were also observed in P. berghei-infected mice. However, COC treatment lowered MDA level and attenuated lipid and lactate alterations in P. berghei infection. This study, therefore, suggests that COC possesses anti-plasmodial potential to mitigate malaria-associated metabolic disturbances. Further animal and human studies are necessary to validate our findings.
  

DOI

10.21608/bfsa.2022.271773

Keywords

Plasmodium berghei, Malaria, COC, Metabolic, Lipid

Authors

First Name

Adam

Last Name

Abdulkareem

MiddleName

Olaitan

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.-Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India.-HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria.

Email

abdulkareem.ao@unilorin.edu.ng

City

-

Orcid

0000-0003-4850-5078

First Name

Abdulkareem

Last Name

Babamale

MiddleName

Olarewaju

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.-Taiwan international Graduate Program in Molecular Medicine, National Yang-Ming Chiao Tung University and Academia Sinica, Taipei ,Taiwan.

Email

babamale.oa@unilorin.edu.ng

City

-

Orcid

-

First Name

Emmanuel

Last Name

Abe

MiddleName

Olusegun

Affiliation

Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.

Email

-

City

-

Orcid

-

First Name

Lawrence

Last Name

Olatunji

MiddleName

Aderemi

Affiliation

Cardiovascular Research Unit, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.-HOPE Cardiometabolic Research Team, University of Ilorin, Ilorin, Nigeria.

Email

tunjilaw@unilorin.edu.ng

City

-

Orcid

-

First Name

Uade

Last Name

Ugbomoiko

MiddleName

Samuel

Affiliation

Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.

Email

-

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-16

Publish Date

2022-12-01

Page Start

925

Page End

934

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 925-934.pdf

PDF . 804.3kB

Link

https://bpsa.journals.ekb.eg/article_271773.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271773

Order

271,773

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMBINED ORAL CONTRACEPTIVE (ETHINYLESTRADIOL/ LEVONORGESTREL) ALLEVIATES LIPID AND LACTATE ALTERATIONS IN PLASMODIUM BERGHEI-INFECTED MICE

Details

Type

Article

Created At

22 Jan 2023