Beta
ManageSearchChatDiscover
271771

STUDY THE PROPHYLACTIC EFFECTS OF MELATONIN AND CYANOCOBALAMIN AGAINST CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

English Cyclophosphamide chemotherapeutic agent, it's used associated with multiorgan toxicity including the heart. Melatonin and cyanocobalamin possess cardiac-protective properties. This study was designed to evaluate the prophylactic effects of melatonin and cyanocobalamin. Fifty adult male rats have used in the study, divided into five groups each containing ten rats, melatonin, and cyanocobalamin were given orally for seven consecutive days before injection of (150 mg/kg) of cyclophosphamide on day seven. Group I: Control group, in which rats were intraperitoneally injected with (1 ml/kg/day) of normal saline. Group II: Rats were intraperitoneally injected with a single dose of cyclophosphamide. Group III: Rats were given orally melatonin at a dose (1 mg/kg/day) and cyclophosphamide. Group IV: Rats were given orally cyanocobalamin at a dose (0.1 mg/kg/day) and cyclophosphamide. Group V: Rats were administered orally a mixture of melatonin at a dose (1 mg/kg/day) and cyanocobalamin at a dose (0.1 mg/kg/day) and cyclophosphamide. On day eight rats were sacrificed, serum and heart extracted for malondialdehyde, interleukin-1 beta, and troponin I measurement, furthermore cardiac immunohistochemical study was performed. It was found that both melatonin and cyanocobalamin significantly (P<0.05) decrease serum levels of malondialdehyde, interleukin-1 beta, and troponin I in comparison with group II and improve immunohistochemical changes in cardiac tissue when compared with the group treated by cyclophosphamide only (group II).  
       

DOI

10.21608/bfsa.2022.271771

Keywords

cyclophosphamide, Melatonin, Cyanocobalamin, Cardiac toxicity

Authors

First Name

Waleed

Last Name

Ghanim

MiddleName

K.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq

Email

ph.wkg81@yahoo.com

City

-

Orcid

0000-0003-4923-9656

First Name

Muhsin

Last Name

Al-Moziel

MiddleName

S.G.

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq

Email

muhsinghalib24@gmail.com

City

-

Orcid

0000-0002-6789-7188

First Name

Karamallah

Last Name

Al-Yousof

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, University of Basra, Basra, Iraq

Email

-

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-11

Publish Date

2022-12-01

Page Start

915

Page End

923

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 915-923.pdf

PDF . 961.1kB

Link

https://bpsa.journals.ekb.eg/article_271771.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271771

Order

271,771

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDY THE PROPHYLACTIC EFFECTS OF MELATONIN AND CYANOCOBALAMIN AGAINST CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY

Details

Type

Article

Created At

22 Jan 2023