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271769

STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS

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Last updated: 25 Dec 2024

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Abstract

The current investigation was carried out to study the protective effect of vitamin E (VE) on the associated disturbances of hematological, renal, and hepatic functions in male rats produced in potassium bromate (KBrO3) treated rats. Twenty-four rats were divided randomly into four groups: First group: served as control group. Second group: rats were received 50 mg/kg b.wt. of KBrO3 orally. Third group: rats were received 30 mg/kg b.wt. of VE orally. Fourth group: rats were received 30 mg/kg b.wt. of VE orally an hour before administration of KBrO3 (50 mg/kg b.wt.) orally. The experiment continued for five successive weeks. Results showed that the treatment with KBrO3 revealed a significantly decrease in the mean of the body weight, red blood corpuscles (RBCs), white blood cells (WBCs), blood platelets (PLTs), hemoglobin (HB), hematocrit value (HCT) comparing to the control group. Whereas, the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes, urea, uric acid, creatinine, were obviously elevated in KBrO3 treated group comparing with control group. The treatment with VE+KBrO3 ameliorated all the hematological, renal, and hepatic parameters tested. It is clear from the present results that VE reduced the severity of KBrO3. This could be mediated by its potent antioxidant effects.
 

DOI

10.21608/bfsa.2022.271769

Keywords

Potassium bromate, Vitamin E, hematological, renal, Hepatic functions

Authors

First Name

Shadia

Last Name

Radwan

MiddleName

A.

Affiliation

Biological and Geological Sciences Departmen, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

shadiaradwan@edu.asu.edu.eg

City

-

Orcid

-

First Name

Aziza

Last Name

El Wessemy

MiddleName

M.

Affiliation

Biological and Geological Sciences Departmen, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Basma

Last Name

Abdel-Aziz

MiddleName

F.

Affiliation

Biological and Geological Sciences Departmen, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

basmalaahmed1285@gmail.com

City

-

Orcid

-

First Name

Enas

Last Name

Abdel-Baky

MiddleName

S.

Affiliation

Biological and Geological Sciences Departmen, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

enas_saleh@edu.asu.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-02-24

Publish Date

2022-12-01

Page Start

903

Page End

913

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 903-913.pdf

PDF . 812.7kB

Link

https://bpsa.journals.ekb.eg/article_271769.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271769

Order

271,769

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS

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Type

Article

Created At

22 Jan 2023