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271766

CARDIOVASCULAR TOXICITY OF CHLORPYRIFOS IN FEMALE ADULT RATS: A PROBABLE PROTECTIVE EFFECT OF PHYTOCHEMICAL ISOFLAVONES

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Last updated: 04 Jan 2025

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Abstract

Chlorpyrifos (CF) an organophosphate insecticide broadly used for pest control and sterilization in agriculture applications. It has also established that CF toxicity linked to the increase of oxidative stress with accumulation of the lipid peroxides. CF poisoning causes the heart tissue to produce high quantity of free radicals, become sensitive to oxidative stress, and damage. Studies indicated that soy contains plenty of isoflavones, mainly genistein (GS), which have antioxidant properties. Current study designed to examine whether GS, daidzein (DZ), or their combination had any protection against CF induced cardiac toxicity in rats. Thirty adult female rats divided into five groups. Group 1 received corn oil. Group 2 received CF 6.7 mg/kg. Group 3 received 6.7 mg/kg CF + 21.7 mg/kg GS. Group 4 received 6.7mg/kg CF + 17.4mg/kg DZ. Group 5 received 6.7mg/kg CF + 21.7 mg/kg GS + 17.4 mg/kg DZ daily oral doses for six weeks. At the end, rats sacrificed and their blood samples and heart tissues collected for biochemical and histopathology analysis. Conclusion: administration of GS or DZ provides a protective effect against oxidative stress induced by CF. However, administration of GS and DZ together synergise oxidative stress induced by CF.
             

DOI

10.21608/bfsa.2022.271766

Keywords

chlorpyrifos, genistein, Daidzein, heart histopathology, troponin, MDA

Authors

First Name

Shigaf

Last Name

Abdulretha

MiddleName

D.

Affiliation

Department of Pharmacology and Toxicology, Institute of Pharmacy, Basra, Iraq

Email

shighafdahham@gmail.com

City

-

Orcid

-

First Name

Asia

Last Name

Abdullah

MiddleName

S.

Affiliation

Department of Pharmacology and Toxicology, Institute of Pharmacy, Basra, Iraq

Email

asiaselman2016@gmail.com

City

-

Orcid

0000-0002-7384-0313

First Name

Muhsin

Last Name

AL‑Moziel

MiddleName

S.

Affiliation

Department of Pharmacology and Toxicology, Institute of Pharmacy, Basra, Iraq

Email

-

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-01-17

Publish Date

2022-12-01

Page Start

895

Page End

902

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 895-902.pdf

PDF . 997.6kB

Link

https://bpsa.journals.ekb.eg/article_271766.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271766

Order

271,766

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CARDIOVASCULAR TOXICITY OF CHLORPYRIFOS IN FEMALE ADULT RATS: A PROBABLE PROTECTIVE EFFECT OF PHYTOCHEMICAL ISOFLAVONES

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Article

Created At

22 Jan 2023