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271691

ASSESSMENT OF NEW PREDICTING BIOMARKERS OF POLLUTION TOXICITY IN WORKERS OR INDIVIDUALS LIVING CLOSE TO OIL REFINERY AREA IN AL-MUTHANNA CITY, IRAQAS ALARM INDICATORS FOR CLINICA

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Last updated: 04 Jan 2025

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Abstract

Objective, This study aims to assess the impact of petroleum exposure on certain biochemical parameters; to find out the sensitive predicting biomarkers which may be considered of a clinical role in detecting the toxic effect of exposure as well as to conclude the possible correlation among the parameters.Methods, 150 individuals were enrolled in this study. The participants were separated into three groups: Group 1 is a control group of 50 people; Group2 is 50 people (who were oil well workers); and Group3 is 50 people (the individuals who live close to oil wells), working in the Middle Refinery Company unit for more than two years. The hematological parameters, serum interleukin 6, serum vitamin D3, serum homocysteine, and serum glutathione were all measured. Results showed significant increases in white blood cells,and platelets in Group2 and Group3 compared to Group1as well as a significant decrease of hemoglobin, hematocrit, and glutathione in workers compared to control groups. Interestingly, we found significant increases in serum interleukin 6 and homocysteine in workers. Conclusions, The individuals who work or live close to oil wells showed significant alterations in some hematological, immunological, and inflammatory parameters,as well as they, revealed more production of reactive oxygen species referring to an increase in oxidative stress.
            

DOI

10.21608/bfsa.2022.271691

Keywords

oil wells, air pollution toxicity, predicting biomarkers

Authors

First Name

Mariam

Last Name

Alghara

MiddleName

Ryadh

Affiliation

BSC in pharmacy, AL Muthanna Health Department, Planning Department, al Muthanna, Iraq

Email

phpg.mariam.ryadh@uobasrah.edu.iq

City

-

Orcid

-

First Name

Ausama

Last Name

Jaccob

MiddleName

Ayob

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Basra University, Basra, Iraq

Email

-

City

-

Orcid

-

First Name

Azza

Last Name

Jabbar

MiddleName

Sajid

Affiliation

Department of Physiology, College of pharmacy, Basra University, Basra, Iraq

Email

azza.jabbar@uobasrah.edu.iq

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-29

Publish Date

2022-12-01

Page Start

883

Page End

893

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 883-893.pdf

PDF . 1.2MB

Link

https://bpsa.journals.ekb.eg/article_271691.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271691

Order

271,691

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSESSMENT OF NEW PREDICTING BIOMARKERS OF POLLUTION TOXICITY IN WORKERS OR INDIVIDUALS LIVING CLOSE TO OIL REFINERY AREA IN AL-MUTHANNA CITY, IRAQAS ALARM INDICATORS FOR CLINICA

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Article

Created At

22 Jan 2023