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271687

ROLE OF HELICOBACTER PYLORI ERADICATION USING CLARITHROMYCIN-BASED TRIPLE THERAPY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME

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Last updated: 25 Dec 2024

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Abstract

Background: Association between Helicobacter pylori (H. pylori) and irritable bowel syndrome (IBS) remains controversial. We evaluated the changes in symptoms and quality of life (QOL) in IBS patients following H. pylori eradication using clarithromycin-based triple therapy. Methods: Patients with moderate or severe IBS and positive H. pylori stool antigen were included and received clarithromycin-based triple therapy, followed by testing for H. pylori eradication after one month. IBS symptoms and IBS-QOL questionnaire were evaluated at the baseline and after H. pylori eradication. Results: 108 patients had H. pylori eradication. Following eradication, 66 patients reported IBS symptoms improvement, while 42 did not. The improved patients were significantly younger; mean age was 38.1 ± 11.7 (p= 0.03). IBS-C type predominated (42.4%) and postprandial fullness and early satiety as dyspeptic symptoms were higher in the improved group. The non-improved group showed a decrease in IBS-QOL subscales, significantly observed in dysphoria, interference with activity, health worry, and social reaction domains. The total IBS-QOL score was significantly higher in the improved versus the non-improved group (p= 0.000). Conclusion: H. pylori eradication did not improve IBS symptoms or QOL in all patients with IBS. QOL improved in young patients with dyspeptic symptoms and the IBS-C subtype.

DOI

10.21608/bfsa.2022.271687

Keywords

eradication, Helicobacter pylori, Irritable bowel syndrome, quality of life, Triple therapy

Authors

First Name

Haidi Karam-Allah

Last Name

Ramadan

MiddleName

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Affiliation

Tropical Medicine and Gastroenterology, Faulty of Medicine, Assiut University.

Email

haidikaram@aun.edu.eg

City

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Orcid

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First Name

Gellan

Last Name

Ahmed

MiddleName

K.

Affiliation

Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt -Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK

Email

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City

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Orcid

-

First Name

Waleed

Last Name

Hassan

MiddleName

Attia

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt

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-

City

-

Orcid

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Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-05-22

Publish Date

2022-12-01

Page Start

859

Page End

868

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 859-868.pdf

PDF . 929.6kB

Link

https://bpsa.journals.ekb.eg/article_271687.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271687

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271,687

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ROLE OF HELICOBACTER PYLORI ERADICATION USING CLARITHROMYCIN-BASED TRIPLE THERAPY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME

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Article

Created At

22 Jan 2023