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271657

ASSOCIATION BETWEEN FOXP3 (RS3761548) PROMOTER POLYMORPHISM WITH VITILIGO PATIENTS, THEIR CLINICAL DATA AND RESPONSE TO PHOTOTHERAPY: A STUDY FROM EGYPT

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Last updated: 25 Dec 2024

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Abstract

Background: The rs3761548 polymorphism (3279 C> A) of the FOXP3 gene is associated with several autoimmune disorders. Its role in vitiligo has not been well studied.We sought to investigate whether rs3761548 polymorphism is associated with vitiligo in Egyptian subjects. Methods:Case-control study where genomic DNA was isolated from blood samples of 100 patients and 100 control subjects and genotyping was done by allele-specific primers. Given that FOXP3 is an X-linked marker, data analysis was done for the entire cohort and then stratified based on the gender. Results:The genotype frequencies differed significantly from patients to control subjects  showing that AC  genotype was significantly higher in the patient group than control subjects  (risky genotype ) despite of the protective nature of CC genotype which observed in our study. According to the alleles , the A allele was higher in the patient than in the control group .Insignificant results were reported according to the association between FOXP3 (rs3761548) promoter polymorphism and  clinical data of patients and their response to phototherapy.Conclusions: The rs3761548 of FOXP3 gene may be associated with susceptibility to vitiligo because of altered expression.Both the A allele and AC genotype were significantly associated with vitiligo .

DOI

10.21608/bfsa.2022.271657

Keywords

foxp3, Vitiligo, Autoimmunity, Egypt

Authors

First Name

Maha

Last Name

Abdelsalam

MiddleName

-

Affiliation

Immunology unit, clinical pathology department, Faculty of medicine, Mansura University, Egypt - Consultant, Immunology Department, Egypt Center for Research and Regenerative Medicine, Cairo 11517, Egypt

Email

dr_mahy20062006@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Zohdy

MiddleName

-

Affiliation

Dermatology Department, Mansura Medical School, Mansura University, Egypt

Email

marwazohdy@mans.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Wassefy

MiddleName

-

Affiliation

Immunology unit, clinical pathology department, Faculty of medicine, Mansura University, Egypt

Email

mona79oam@gmail.com

City

-

Orcid

-

First Name

Azza

Last Name

Salamony

MiddleName

-

Affiliation

Consultant, Immunology Department, Egypt Center for Research and Regenerative Medicine, Cairo 11517, Egypt- Microbiology and Immunology, Central Public Health laboratories, CPHL, Ministry of Health, Cairo, 11613, Egypt

Email

azzasalamony@yahoo.com

City

-

Orcid

-

First Name

shaimaa

Last Name

mohsen

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Egypt Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Badr University in Cairo, Egypt

Email

dr_shaimaamohsen@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Elmansoury

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt

Email

dr_eman_elmansoury@yahoo.com

City

-

Orcid

-

First Name

Maged

Last Name

Mostafa

MiddleName

-

Affiliation

Immunology unit, clinical pathology department, Faculty of medicine, Mansura University, Egypt

Email

magedmostafa1981@gmail.com

City

-

Orcid

0000-0001-9723-2710

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-06-12

Publish Date

2022-12-01

Page Start

833

Page End

843

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 833-843.pdf

PDF . 871.0kB

Link

https://bpsa.journals.ekb.eg/article_271657.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271657

Order

271,657

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSOCIATION BETWEEN FOXP3 (RS3761548) PROMOTER POLYMORPHISM WITH VITILIGO PATIENTS, THEIR CLINICAL DATA AND RESPONSE TO PHOTOTHERAPY: A STUDY FROM EGYPT

Details

Type

Article

Created At

22 Jan 2023