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271645

PREVALENCE OF ANTIBIOTICS RESISTANCE AMONG PATIENTS UNDERGOING BRONCHOSCOPY IN CHEST DEPARTMENT AT AL-SHIFA MEDICAL COMPLEX IN GAZA STRIP, PALESTINE

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Last updated: 04 Jan 2025

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Abstract

Background: This study was conducted to determine the prevalence of antibiotics resistance among patients undergoing bronchoscopy in Chest Department at Al-Shifa Medical Complex. Method: This cross-sectional study was conducted in year 2021. A total of 88 patients who were admitted to the Chest Department to undergo bronchoscopy during the study period were included. A 176-bronchoalveolar lavage (BAL) samples were stained and cultured for bacteria and fungi. Isolated bacteria from the BAL samples were identified, and antimicrobial susceptibility testing was conducted. Statistical analysis was performed using the SPSS version 22 program. Results: Fifty-five (62.5%) of the patients were males, and 33(37.5%) were females. About 47(53.4%) of the BAL samples were positive bacterial cultures; 32(36.4%) of the BAL samples were positive fungal cultures. Among the isolated 39(83%) gram-positive bacteria, Streptococcus pneumoniae bacteria was the predominant pathogen in 35(89.7%) isolates. Among the isolated eight (17%) gram-negative bacteria, Pseudomonas aeruginosa was found to be the predominant organism in four (50%) isolates. Among the total of 32 fungal isolates samples, 15(46.9%) were Candida fungi detected, making it the most predominant pathogen. Conclusion: All bacteria as Streptococcus pneumoniae, Staphylococcal aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae were multiple drug resistance bacteria. Streptococcus pneumoniae is mainly susceptible to Rifampicin, whereas Gentamicin and Rifampicin are effective antimicrobial agents against Staphylococcal aureus. The effective antimicrobial agents against Pseudomonas aeruginosa were Amikacin, Colistin, Ceftazidime and Ciprofloxacin. Colistin and Doxycycline were the best effective drugs against each of Klebsiella pneumoniae and Escherichia coli. Additionally, Candida fungi were the most predominant pathogens.

DOI

10.21608/bfsa.2022.271645

Keywords

Antimicrobial resistance, Bronchoalveolar lavage, Chest Department, Gaza Strip, Multi-drug resistance

Authors

First Name

Mahmoud

Last Name

Taleb

MiddleName

Hussien

Affiliation

Department of Pharmacology and Medical Sciences, Faculty of Pharmacy, Al Azhar University of Gaza, Palestine

Email

mahtaleb@hotmail.com

City

-

Orcid

-

First Name

Emad

Last Name

Elkhair

MiddleName

Abou

Affiliation

Department of Biology, Faculty of Science, Al-Azhar University-Gaza, Palestine

Email

-

City

-

Orcid

-

First Name

Rolla

Last Name

Timraz

MiddleName

Abed

Affiliation

Ministry of Health, Gaza, Palestine

Email

-

City

-

Orcid

-

First Name

Abdel Hamid

Last Name

El Bilbeisi

MiddleName

Hassan

Affiliation

Department of Nutrition, School of Medicine and Health Sciences, University of Palestine, Gaza Strip, Palestine

Email

abed_az@hotmail.com

City

Gaza

Orcid

0000-0001-8870-8326

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-25

Publish Date

2022-12-01

Page Start

811

Page End

822

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 811-822.pdf

PDF . 1.5MB

Link

https://bpsa.journals.ekb.eg/article_271645.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271645

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271,645

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREVALENCE OF ANTIBIOTICS RESISTANCE AMONG PATIENTS UNDERGOING BRONCHOSCOPY IN CHEST DEPARTMENT AT AL-SHIFA MEDICAL COMPLEX IN GAZA STRIP, PALESTINE

Details

Type

Article

Created At

22 Jan 2023