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271641

THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS

Article

Last updated: 04 Jan 2025

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Abstract

Objective: Patients with liver cirrhosis have different complications including bleeding disorders, due to vitamin K-dependent coagulation factors deficiency. Vitamin K is administered to correct bleeding complications, however the evidence for its efficacy either orally or intravenously is lacking. This study aimed to assess therapeutic role of vitamin K in cirrhotic patients.Methods: A prospective observational study was conducted on ninety liver cirrhotic patients at Al-Rajhy Liver Hospital. Patients received vitamin K orally (N= 45) or intravenously (N=  45) at doses of 10 mg/day for 3 successive days. Prothrombin time (PT), international normalization ratio (INR), serum vitamin K level, hemoglobin, liver and kidney function were assessed at baseline and after 3 days of vitamin K administration. Child-Pugh score and bleeding signs were reported. Results: After vitamin K administration, vitamin K serum level was significantly increased in the oral and the IV group. PT and INR were significantly decreased in the oral and the IV groups. Vitamin K serum level had negative significant correlation with PT (r=  -0.42, P= 0.033) and INR (r=  -0.40, P= 0.038). Conclusion: Oral and IV vitamin K administration showed similar efficacy in improving PT, INR and bleeding signs. Child B class patients more benefited from vitamin k administration than Child C class..

DOI

10.21608/bfsa.2022.271641

Keywords

intravenous, INR, Liver cirrhosis, Oral, PT, Vitamin K

Authors

First Name

Tarek

Last Name

Mohameed

MiddleName

Refaat

Affiliation

Clinical Pharmacy Unit, Al-Rajhy Liver Hospital, Assuit, Egypt.

Email

-

City

-

Orcid

-

First Name

Haidi

Last Name

Ramadan

MiddleName

Karam-Allah

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assuit University.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Latif

MiddleName

Mahmoud

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assuit University.

Email

m.abdellatif@aun.edu.eg

City

-

Orcid

-

First Name

Sahar

Last Name

Hassan

MiddleName

Badr

Affiliation

Department of Clinical Pharmacy, Faculty of Pharmacy, Assuit University

Email

sahar.badr@pharm.aun.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-14

Publish Date

2022-12-01

Page Start

789

Page End

800

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 789-800.pdf

PDF . 709.8kB

Link

https://bpsa.journals.ekb.eg/article_271641.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271641

Order

271,641

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS

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Type

Article

Created At

22 Jan 2023