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271600

DEVELOPMENT OF FOUR UV-SPECTROMETRIC TECHNIQUES FOR CONCURRENT ESTIMATION OF ASPIRIN AND SILDENAFIL CITRATE IN THEIR BINARY MIXTURE AND PHARMACEUTICAL FORMULATIONS

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Last updated: 25 Dec 2024

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Abstract

The combination of aspirin (ASP) and sildenafil citrate (SIL) into single dosage form has been of interest for a considerable period; because it has a synergistic effect for the handling of many diseases. Therefore, UV-spectrometric techniques were desperately required for the concurrent estimation of ASP and SIL in their binary mixture and pharmaceutical formulations. In this paper, four simple, low-cost and precise UV-spectrometric techniques were evolved for the concurrent estimation of ASP and SIL. The advanced methods include treatment of the zero-order spectrum by ratio subtraction (RS) along with spectrum subtraction method (SS), absorption correction method (ACM), area under the curve correction method (AUCCM) and induced dual wavelength method (IDWM). Moreover, UV-spectrometric purity analysis via spectral ratio factor (SRF) was developed; which considered the first UV-spectrometric purity testing to verify the purity of ASP in pharmaceuticals formulations.
All approaches were linear; in the range of 25.0-100.0 μg/mL for ASP, and 10.0-50.0 μg/mL for SIL. The mean percentage recoveries for ASP were 100.92, 100.33, 100.79 and 100.18% respectively, and for SIL were 99.27, 99.56, 99.83 and 99.44% respectively. The SRF values were approximating unity and showed high purity of the resolved peaks. The results were statistically compared with the HPLC reported method and no significant variance was discerned.  

DOI

10.21608/bfsa.2022.271600

Keywords

aspirin, Concurrent estimation, sildenafil, UV-Spectrometric techniques

Authors

First Name

Amir

Last Name

Alhaj Sakur

MiddleName

-

Affiliation

Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo city, Syria.

Email

profsakur@gmail.com

City

Aleppo

Orcid

0000-0002-3103-2916

First Name

Zahraa

Last Name

Kayali

MiddleName

-

Affiliation

Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

kayali.zahr@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-29

Publish Date

2022-12-01

Page Start

761

Page End

773

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 761-773.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_271600.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271600

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271,600

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DEVELOPMENT OF FOUR UV-SPECTROMETRIC TECHNIQUES FOR CONCURRENT ESTIMATION OF ASPIRIN AND SILDENAFIL CITRATE IN THEIR BINARY MIXTURE AND PHARMACEUTICAL FORMULATIONS

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Type

Article

Created At

22 Jan 2023