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271598

FOURIER TRANSFORM INFRARED SPECTROSCOPY FOR QUANTITATIVE DETERMINATION OF VALSARTAN IN BULK MATERIALS AND IN PHARMACEUTICAL DOSAGE FORMS

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Last updated: 25 Dec 2024

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Abstract

The present paper illustrates the potential applications of Fourier Transform Infrared Spectroscopy (FT-IR) in pharmaceutical analysis. A simple, rapid, non-destructive and green (FT-IR) spectroscopy method for quality control evaluation of valsartan was developed, using potassium bromide (KBr) as a matrix to quantify the drug in bulk pharmaceutical materials and in pharmaceutical dosage forms. The sample preparation was avoided except grinding for disk composition and excluded the use of organic solvents. Absorbance obtained for the carbonyl band (C=O) located at 1732 cm-1 was used for the development of calibration curve based on simple Beer-lambert's law. Method validation was performed according to the International Conference on Harmonization (ICH) guidelines. Linearity, accuracy, precision, robustness and selectivity were evaluated and showed acceptable results for method validation in the concentration range of (0.5 - 2.5% w/w). The developed and validated method was suitable for the quality control analysis of valsartan in bulk materials and in pharmaceutical dosage forms.

DOI

10.21608/bfsa.2022.271598

Keywords

FT-IR, quantitative, absorbance

Authors

First Name

Najwa

Last Name

Harshou

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

najwa.harsho@gmail.com

City

-

Orcid

-

First Name

Saleh

Last Name

Trefi

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

trefiquality@gmail.com

City

-

Orcid

-

First Name

Yaser

Last Name

Bitar

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

dr.ybitar@hotmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-20

Publish Date

2022-12-01

Page Start

747

Page End

760

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 747-760.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_271598.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271598

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271,598

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FOURIER TRANSFORM INFRARED SPECTROSCOPY FOR QUANTITATIVE DETERMINATION OF VALSARTAN IN BULK MATERIALS AND IN PHARMACEUTICAL DOSAGE FORMS

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Article

Created At

22 Jan 2023