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271592

EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES

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Last updated: 04 Jan 2025

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Abstract

The emergence of resistance in the immunocompromised patients against existing anticandidal agents makes them ineffective causing high incidence and accompanying mortality due to the fungal infections. The generation of biofilms by various species of candida is the most frequent underlying mechanism in the emergence of resistance. Biofilms are defined as encapsulated complex microbial colonies in extracellular polymeric substances (EPS) matrix. The development of newer anticandidal with lower resistance remains a challenging task for researchers. We herein report, a series of N-(substituted benzylidene)-4,6-dimethoxypyrimidin-2-amine analogs along with their antibiofilm and anticandidal potential in-vitro. Compounds 3a, 3b, 3i, 3k, and 3l have shown better inhibition against C. albicans than Fluconazole (standard anticandidal agent). Compounds 3a, 3b, and 3i also exhibited good antibiofilm activity suggesting their antibiofilm as well as anticandidal potential. The results show that the new compounds could serve as an important lead in the discovery of effective anticandidal agents to overcome the resistance problem associated with the existing anticandidal agents.

DOI

10.21608/bfsa.2022.271592

Keywords

Pyrimidine Schiff bases, Anticandidal activity, Antifungal, Antibiofilm

Authors

First Name

Shahebaaz

Last Name

Pathan

MiddleName

K.

Affiliation

Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad- (MS) India

Email

kshahebaaz@gmail.com

City

-

Orcid

0000-0002-4071-9103

First Name

Rajendra

Last Name

Patil

MiddleName

H.

Affiliation

Department of Biotechnology, Savitribai Phule Pune University, Pune 4110007

Email

rpatil@unipune.ac.in

City

-

Orcid

0000-0003-0534-7356

First Name

Jaiprakash

Last Name

Sangshetti

MiddleName

N.

Affiliation

Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad- (MS) India

Email

jnsangshetti@rediffmail.com

City

-

Orcid

0000-0002-9064-4111

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-04-16

Publish Date

2022-12-01

Page Start

685

Page End

693

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 685-693.pdf

PDF . 685.3kB

Link

https://bpsa.journals.ekb.eg/article_271592.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271592

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271,592

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EXPLORING ANTICANDIDAL AND ANTIBIOFILM POTENTIALS OF SYNTHESIZED N-(SUBSTITUTEDBENZYLIDENE)-4,6-DIMETHOXYPYRIMIDIN-2-AMINE ANALOGUES

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Article

Created At

22 Jan 2023