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271589

ESSENTIAL OIL COMPOSITION AND CYTOTOXICITY OF Decaspermum parviflorum (Lam.) A.J.Scott FROM MALAYSIA

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Last updated: 04 Jan 2025

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Abstract

The present study analyzed the chemical composition and evaluated the cytotoxicity of essential oil extracted from Decaspermum parviflorum (Lam.) A.J.Scott (Myrtaceae). The chemical composition of the essential oil was analyzed using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Thirty-five components were identified, accounting for 97.3% and comprising mainly of monoterpene hydrocarbons, 52.5%. α-Pinene (40.5%), β-pinene (9.2%), β-eudesmol (8.0%), globulol (7.5%), and β-caryophyllene (5.1%) were identified as its major components. The oil exhibits potent cytotoxicity (IC50 values of 68.5-70.2 μg/mL) against three human cancer cell lines; HepG2 (liver), MCF7 (breast), and A549 (lung). This is the first report on the chemical composition and cytotoxicity of D. parviflorum essential oil from the context of Malaysia in this study. The present study highlights the potential of using essential oil as an excellent alternative for the development of anticancer chemotherapeutic agents for the pharmaceutical industry

DOI

10.21608/bfsa.2022.271589

Keywords

Myrtaceae, Decaspermum parviflorum, essential oil, α-pinene, Cytotoxicity

Authors

First Name

Wan Mohd Nuzul Hakimi Wan

Last Name

Salleh

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia

Email

wmnhakimi@fsmt.upsi.edu.my

City

Tanjung Malim

Orcid

0000-0003-1408-229X

First Name

Nurunajah

Last Name

Ghani

MiddleName

Ab.

Affiliation

Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia- Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

Email

-

City

-

Orcid

-

First Name

Abu-Baker

Last Name

bdel-Aal

MiddleName

M. A

Affiliation

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia-Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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-

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Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-08-09

Publish Date

2022-12-01

Page Start

679

Page End

684

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 679-684.pdf

PDF . 588.3kB

Link

https://bpsa.journals.ekb.eg/article_271589.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271589

Order

271,589

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ESSENTIAL OIL COMPOSITION AND CYTOTOXICITY OF Decaspermum parviflorum (Lam.) A.J.Scott FROM MALAYSIA

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Type

Article

Created At

22 Jan 2023