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271588

ANTI-INFLAMATORY AND ANTI-LIPID PEROXODATION POTENTIALS OF SALVIA CHUDAEI BATT. et TRAB. AND LAVANDULA ANTINEAE MAIRE: ENDEMIC PLANTS FROM ALGERIAN SAHARA

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Last updated: 04 Jan 2025

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Abstract

The present study was undertaken to investigate the anti-inflammatory and anti-lipid peroxidation activities of two endemic plants of the central Sahara; Salvia chudaei Batt. et Trab and Lavandula antineae Maire (Lamiaceae), as well as their chemical composition of hydromethanolic extracts. In the test of carrageenan-induced oedema in mice, L. antineae extract, at the dose of 200 mg/kg, revealed good anti-inflammatory activity (P˂0.05) showing 80.74% reduction in the paw thickness comparable to that produced by the standard drug aspirin an83.44% at 4h, while S. chudaei extract was found to have moderate activity (50.74%). When the plant extracts were applied topically at a dosage of 1 and 2 mg per ear, the reduction of ear oedema inflammation was very remarkable compared to the mice of the control group. The plant extracts also showed anti-lipid peroxidation activity with no significant difference compared to ascorbic acid (77.63 ± 1.58%). In addition, the chemical characterization of two extracts by HPLC-DAD revealed the presence of various phenolic acids and flavonoids. These findings showed that Lavandula antineae and Salvia chudaei displays remarkable anti-inflammatory and anti-lipid peroxidation activities and hence can be potential natural sources in health and medicine.

DOI

10.21608/bfsa.2022.271588

Keywords

Lavandula antineae, Salvia chudaei, anti-inflammatory, anti-lipid peroxidation activities, HPLC-DAD analysis

Authors

First Name

Soumeya

Last Name

Krimat

MiddleName

-

Affiliation

Laboratory of Bioactive Products and Biomass Valorization Research. ENS Kouba, BP92, Vieux Kouba Alger, Algeria

Email

krimatsoumia.2012@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Nouasri

MiddleName

-

Affiliation

Laboratory of Bioactive Products and Biomass Valorization Research. ENS Kouba, BP92, Vieux Kouba Alger, Algeria

Email

a_nouasridz2001@yahoo.fr

City

-

Orcid

-

First Name

Aicha

Last Name

Ksouri

MiddleName

-

Affiliation

Laboratory of Bioactive Products and Biomass Valorization Research. ENS Kouba, BP92, Vieux Kouba Alger, Algeria

Email

ksouri_aicha@hotmail.com

City

-

Orcid

-

First Name

Hafidha

Last Name

Metidji

MiddleName

-

Affiliation

Laboratory of Bioactive Products and Biomass Valorization Research. ENS Kouba, BP92, Vieux Kouba Alger, Algeria

Email

-

City

-

Orcid

-

First Name

Chafia

Last Name

Tigrine

MiddleName

-

Affiliation

Tigrine Chafia, Laboratory of Ethnobotany and Natural Substances, ENS Kouba. BP92, vieux kouba Alger, Algeria

Email

tigrinechaf@yahoo.fr

City

-

Orcid

-

First Name

Tahar

Last Name

Dob

MiddleName

-

Affiliation

Laboratory of Bioactive Products and Biomass Valorization Research. ENS Kouba, BP92, Vieux Kouba Alger, Algeria

Email

t_dob2010@yahoo.co.uk

City

-

Orcid

0000-0002-6067-4248

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-07-17

Publish Date

2022-12-01

Page Start

667

Page End

677

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 667-677.pdf

PDF . 846.1kB

Link

https://bpsa.journals.ekb.eg/article_271588.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271588

Order

271,588

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTI-INFLAMATORY AND ANTI-LIPID PEROXODATION POTENTIALS OF SALVIA CHUDAEI BATT. et TRAB. AND LAVANDULA ANTINEAE MAIRE: ENDEMIC PLANTS FROM ALGERIAN SAHARA

Details

Type

Article

Created At

22 Jan 2023