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271487

LIPID NANOEMULSION-BASED LIQUISOLID COMPACT TABLETS FOR ORAL DELIVERY OF CLOTRIMAZOLE: FABRICATION STRATEGIES, CHARACTERIZATIONS, ANTIMYCOTIC AND TOXICOLOGICAL EVALUATIONS

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Last updated: 04 Jan 2025

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Abstract

This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)-loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections. Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and non-pharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. LNE was nanosized (66.7 ± 5.7 – 121.6 ± 3.2 nm). Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 – 346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 – 99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 – 5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.

DOI

10.21608/bfsa.2022.271487

Keywords

Clotrimazole, Lipid nanoemulsion, Liquisolid, Systemic mycoses, Candida albicans, Oral delivery

Authors

First Name

Chukwuebuka

Last Name

Umeyor

MiddleName

Emmanuel

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

ec.umeyor@unizik.edu.ng

City

-

Orcid

-

First Name

Ifeyinwa

Last Name

Ezechukwu

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

ifecordy1984@gmail.com

City

-

Orcid

-

First Name

Chiamaka

Last Name

Okafor

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

cevalp2000@yahoo.com

City

-

Orcid

-

First Name

Marksaviour

Last Name

Ibe

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

chuks4live@gmail.com

City

-

Orcid

-

First Name

Tochukwu

Last Name

Okeke

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

ct.okeke@unizik.edu.ng

City

-

Orcid

-

First Name

Ngozi

Last Name

Nebolisa

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

nebmaryann@gmail.com

City

-

Orcid

0009-0000-0610-2524

First Name

Emmanuel

Last Name

Uronnachi

MiddleName

-

Affiliation

Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, 422001, Anambra State, Nigeria

Email

em.uronnachi@unizik.edu.ng

City

-

Orcid

-

First Name

Anthony

Last Name

Attama

MiddleName

-

Affiliation

Drug Delivery and Nanomedicine Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

Email

anthony.attama@unn.edu.ng

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-05-08

Publish Date

2022-12-01

Page Start

533

Page End

564

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 533-564.pdf

PDF . 2.5MB

Link

https://bpsa.journals.ekb.eg/article_271487.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271487

Order

271,487

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

LIPID NANOEMULSION-BASED LIQUISOLID COMPACT TABLETS FOR ORAL DELIVERY OF CLOTRIMAZOLE: FABRICATION STRATEGIES, CHARACTERIZATIONS, ANTIMYCOTIC AND TOXICOLOGICAL EVALUATIONS

Details

Type

Article

Created At

22 Jan 2023