Beta
ManageSearchChatDiscover
271486

PREPARATION AND EVALUATION OF COMPRESSED COATED TABLETS USING POLYELECTROLYTE COMPLEX FOR TARGETED DELIVERY OF ANTI-AMOEBIC DRUG

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

An unwanted absorption of anti-amoebic drug at upper gastrointestinal tract (GIT) causes numerous side effects and requires higher doses to get therapeutic effect. The primary goal of this study was to develop a secnidazole colon targeted drug delivery system (CTDDS) employing compressed coated tablets (CCT) coated with polyelectrolyte complexes (PECs). The optimized PEC was formulated by using varying ratios of cationic and anionic polymers which have the ability to resist a wide range of pH environment from stomach to colon (acidic, neutral to basic). The in vitro release profile of drug was studied in various simulated physiological conditions i.e., gastric, intestinal and colonic environment. For in vivo evaluation, barium sulfate imaging x-ray technique was used to evaluate the transit behavior of formulation in GIT. The results obtained from physical evaluation have demonstrated uniform diameter, thickness, desired hardness (> 4 kg/cm2), and friability (not more than 1.0%). The Korsmeyer-Peppas model suggested the kinetics of drug release as ‘n> 0.89'   which indicates super case–II transport mechanism. In vivo images have confirmed that the tablet formulations were not disintegrated in the upper stomach and degraded in the colonic area.

DOI

10.21608/bfsa.2022.271486

Keywords

Polyelectrolyte complex, Compressed coated tablets, Anti-amoebic drug, Cationic anionic polymers, Targeted delivery

Authors

First Name

Vaibhav

Last Name

Tiwari

MiddleName

-

Affiliation

Shri Shankaracharya Institute of Pharmaceutical Science and Research, Junwani, Bhilai, Chhattisgarh, India- 490020

Email

drvaibhavpharmacy@gmail.com

City

-

Orcid

-

First Name

Jawahar

Last Name

Dangi

MiddleName

Singh

Affiliation

Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495009 India

Email

drjsdangi@rediffmail.com

City

-

Orcid

-

First Name

Sangeeta

Last Name

Tiwari

MiddleName

-

Affiliation

Shri Shankaracharya Institute of Pharmaceutical Science and Research, Junwani, Bhilai, Chhattisgarh, India- 490020

Email

sangeetapharmacology@gmail.com

City

-

Orcid

-

First Name

Leena

Last Name

Kumari

MiddleName

-

Affiliation

School of Pharmacy, Techno India University, Kolkata-700091, West Bengal, India

Email

leenasahu823@gmail.com

City

-

Orcid

-

First Name

Alok

Last Name

Thakur

MiddleName

Singh

Affiliation

Shri Shankaracharya Institute of Pharmaceutical Science and Research, Junwani, Bhilai, Chhattisgarh, India- 490020

Email

aloksinghthakur19852@gmail.com

City

-

Orcid

-

First Name

Hemant

Last Name

Badwaik

MiddleName

Ramchandra

Affiliation

Shri Shankaracharya Institute of Pharmaceutical Science and Research, Junwani, Bhilai, Chhattisgarh, India- 490020

Email

hemantrbadwaik@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-31

Publish Date

2022-12-01

Page Start

517

Page End

532

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 517-532.pdf

PDF . 1.8MB

Link

https://bpsa.journals.ekb.eg/article_271486.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271486

Order

271,486

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREPARATION AND EVALUATION OF COMPRESSED COATED TABLETS USING POLYELECTROLYTE COMPLEX FOR TARGETED DELIVERY OF ANTI-AMOEBIC DRUG

Details

Type

Article

Created At

22 Jan 2023