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271485

NANOSTRUCTURED LIPOSOMES FOR NOSE TO BRAIN DELIVERY OF CARMUSTINE: IN VIVO EVALUATION

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Last updated: 25 Dec 2024

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Abstract

Nano sized particles are promising mediators for the administration of active compounds in the nasal and cerebral systems. However, the ability to achieve relevant therapeutic concentrations of exogenous molecules in the body is dependent mainly on the capability of nanoparticles to break down biological obstructions. In this work, nanoscale formulations conveying the minimally soluble model drug Carmustine (CS) were discussed. Box Behnken design (QbD tool) was applied to predict the interactions between the independent variable (drug-lipid ratio (X1), cholesterol (X2) and Critical Process Parameters (sonication time, X3) on the dependent variable (Entrapment efficiency (Y1), Particle size (Y2) and in vitro drug release (Y3)).  The nano scale liposomal optimized Carmustine formulation (NSL-OCS) was investigated for their effect on the biopharmaceutical facets decisive for nose-to-brain delivery such as permeation across the nasal mucosa. An in vivo pharmacokinetic study was performed in Wistar albino rats via intravenous routes. Histopathologic studies support the absence of evidence of toxicity. In vitro drug dissemination studies show rapid drug release followed by extended release of CS for up to 24 hrs. The Pharmacokinetic parameters of NSLs in brain were higher in intranasal route compared to NSLs administered by intravenous route. The findings showed that the intranasal pathway can be an effective approach to administering the drug straight to the brain and improve the drug's efficacy in the brain to treat brain tumors and become a good substitute to oral medication.

DOI

10.21608/bfsa.2022.271485

Keywords

Box Behnken design, Carmustine, intranasal, liposomes

Authors

First Name

G.

Last Name

Vani

MiddleName

Nethra

Affiliation

Research Scholar, Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India

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Orcid

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First Name

M.

Last Name

Alagusundaram

MiddleName

-

Affiliation

Department of Pharmaceutics, Ratnam Institute of Pharmacy, Nellore, Andhra Pradesh, India

Email

-

City

-

Orcid

-

First Name

K.B.

Last Name

Sekhar

MiddleName

Chandra

Affiliation

Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India

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Orcid

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Volume

45

Article Issue

2

Related Issue

37882

Issue Date

2022-12-01

Receive Date

2022-03-17

Publish Date

2022-12-01

Page Start

507

Page End

516

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 2_Pages 507-516.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_271485.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=271485

Order

271,485

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NANOSTRUCTURED LIPOSOMES FOR NOSE TO BRAIN DELIVERY OF CARMUSTINE: IN VIVO EVALUATION

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Article

Created At

22 Jan 2023