Beta
ManageSearchChatDiscover
239626

THE EFFECTS OF NITRIC OXIDE WITHIN THE DORSAL HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY IN MALE NMRI STRESSED MICE

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Nitric oxide is an essential neurotransmitter in the hippocampus involved in spatial learning and memory and response to stress. This study investigated the effects of nitric oxide within the dorsal hippocampus on spatial learning and memory in male NMRI stressed mice. Male NMRI (Naval Medical Research Institute) mice (n= 7/group) were divided into; Saline, L-NAME (L-Nitro-Arginine Methyl Ester) (1, 5, 10 µg/mouse), and L-Arginine (1, 5, 10 µg/mouse) groups. Seven days after bilateral intra dorsal hippocampus cannulation, half of the animals received electro foot shock stress once/day, for four consecutive days. Barnes maze method was applied for the evaluation of stress effects on spatial learning and memory. Elapsed time and distance traveled to reach the target hole, and the numbers of errors were calculated as spatial learning and memory performance indicators. Stress increases the time and distance for reaching the target hole. The number of errors also was increased in the stress group. Intra dorsal hippocampus administration of L-arginine reduced the stress-induced spatial learning and memory deficit. The drug reduced the time and distance for reaching the target hole. L-NAME also reduced the stress effect. The drug reduced the time and distance for reaching the target hole. Since both the inhibition of NO synthesis and increasing the NO synthesis in the dorsal hippocampus resulted in learning and memory improvements in mice exposed to electro foot shock stress, NO in the dorsal hippocampus might be involved in stress-related spatial learning and memory deficits.

DOI

10.21608/bfsa.2022.239626

Keywords

Dorsal Hippocampus, L-arginine, L-NAME, Nitric oxide, Spatial Learning and Memory

Authors

First Name

Mohammad

Last Name

Sahraei

MiddleName

-

Affiliation

School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Email

mohammadsahraei1374@yahoo.com

City

-

Orcid

-

First Name

Atusa

Last Name

Mashhadi

MiddleName

-

Affiliation

Department of Biology, North Tehran branch, Islamic Azad University, Tehran, Iran

Email

atuashhadi.bms@gmail.com

City

-

Orcid

-

First Name

Hossein

Last Name

Meftahi

MiddleName

-

Affiliation

Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Email

-

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-10-17

Publish Date

2022-06-01

Page Start

481

Page End

492

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 481-492.pdf

PDF . 850.9kB

Link

https://bpsa.journals.ekb.eg/article_239626.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239626

Order

41

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE EFFECTS OF NITRIC OXIDE WITHIN THE DORSAL HIPPOCAMPUS ON SPATIAL LEARNING AND MEMORY IN MALE NMRI STRESSED MICE

Details

Type

Article

Created At

22 Jan 2023