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239624

HEPATOPROTECTIVE EFFECTS OF VITAMIN C AGAINST METHOTREXATE INDUCED ACUTE LIVER INJURY: AN EXPERIMENTAL STUDY

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Last updated: 04 Jan 2025

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Abstract

Methotrexate (MTX), a synthetic antimetabolite with a wide range of therapeutic indications, although its liver toxicity induced mainly through oxidative stress limits its clinical use. Vitamin C (ascorbic acid) possesses potent antioxidant and anti-inflammatory properties, Therefore, has a possible hepatoprotective effect. This study seeks to address the hepatoprotective effects of vitamin C against MTX-induced liver injury in albino mice. MTX showed significant elevation in both serum Alanine aminotransferase (ALT) and liver tissue Malondialdehyde (MDA), indicating hepatic injury, while vitamin C pre-treatment will hold down this elevation significantly and dose-dependently, causing amelioration of the toxic effect of MTX; the histopathological findings also support this finding. Also, MTX causes consumption of liver tissue content of superoxide dismutase (SOD) and Glutathione (GSH), while vitamin C pre-treatment boosts the SOD hepatic tissue level while GSH is diminished even more.  In conclusion, vitamin C has a dose-dependent amelioration effect on the toxic effect of MTX on the liver.

DOI

10.21608/bfsa.2022.239624

Keywords

Methotrexate, vitamin c, Hepatotoxicity, Liver, Oxidative Stress

Authors

First Name

Ali

Last Name

Al-Gareeb

MiddleName

-

Affiliation

Department of Pharmacology, College of Medicine, University of Al-Mustansiriya, Baghdad-Iraq

Email

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City

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Orcid

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First Name

Ghaith

Last Name

Mohammed

MiddleName

F.

Affiliation

Department of Pharmacology, College of Medicine, University of Al-Mustansiriya, Baghdad-Iraq

Email

ghaithfaris28@gmail.com

City

-

Orcid

0000-0002-2237-6928

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-08-29

Publish Date

2022-06-01

Page Start

459

Page End

468

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 459-468.pdf

PDF . 821.6kB

Link

https://bpsa.journals.ekb.eg/article_239624.html

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https://bpsa.journals.ekb.eg/service?article_code=239624

Order

39

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

HEPATOPROTECTIVE EFFECTS OF VITAMIN C AGAINST METHOTREXATE INDUCED ACUTE LIVER INJURY: AN EXPERIMENTAL STUDY

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Article

Created At

22 Jan 2023