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239586

INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA

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Last updated: 25 Dec 2024

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Abstract

The aim of this study was to investigate bacteria isolated from diabetic foot ulcers (DFUs), and determine their antibiotic sensitivity patterns that helps clinicians to select appropriate antimicrobial therapy. The study included 65 patients with DFUs who were admitted to Al-Basel Hospital in Homs, Syria between May 2020 and December 2020. Bacteria were isolated from foot lesions and identified by colonial morphology, gram staining and biochemical reactions. Antibiotic sensitivity of isolates was determined using the Kirby-Bauer disk diffusion method. A total of 89 bacterial isolates were obtained from 63 patients. Gram-positive bacteria were more common (58%) than gram-negative bacteria (42%). Staphylococcus aureus was the most prevalent isolate (29%), followed by Pseudomonas aeruginosa (13%) and Streptococcus agalactiae (11%). The antibiotic imipenem was the most effective against both gram-positive and gram-negative bacteria. In addition to imipenem, vancomycin and linezolid were the most effective antibiotics against gram-positive bacteria, while gentamicin and amikacin were the most effective antibiotics against gram-negative bacteria. This study showed low levels of sensitivity to self-administered antibiotics. Therefore, there is a need to avoid excessive use of antibiotics and improve antimicrobial stewardship programs.

DOI

10.21608/bfsa.2022.239586

Keywords

diabetic foot ulcers, sensitivity patterns, antimicrobial stewardship

Authors

First Name

Lara

Last Name

Al Abbas

MiddleName

Atassi

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, AL Baath University, Homs, Syria

Email

alabbaslara@gmail.com

City

-

Orcid

-

First Name

Walid

Last Name

Khaddam

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, AL Baath University, Homs, Syria

Email

waleedkhaddam@gmail.com

City

-

Orcid

-

First Name

Fahd

Last Name

Shreibati

MiddleName

-

Affiliation

Department of Surgery, Faculty of Medicine, AL Baath University, Homs, Syria

Email

dr.fahdshreibati67@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2022-01-02

Publish Date

2022-06-01

Page Start

451

Page End

458

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 451-458.pdf

PDF . 654.3kB

Link

https://bpsa.journals.ekb.eg/article_239586.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239586

Order

38

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INVESTIGATING BACTERIA ISOLATED FROM DIABETIC FOOT ULCERS AND STUDYING THEIR SENSITIVITY TO ANTIBIOTICS –SYRIA

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Article

Created At

22 Jan 2023