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239584

ASPERGILLUS NIGER AS A BIO-LAB FOR EXTRACELLULAR SYNTHESIS OF SILVER NANOPARTICLES AND ITS ANTIBACTERIAL ACTIVITY

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Last updated: 25 Dec 2024

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Abstract

Antibiotic resistance is one of the world's maximum urgent public healthcare problems. Silver nanoparticles (AgNPs) are appealing alternative due to the fact they may be non-poisonous to the human frame at low concentrations and feature antibacterial actions. The present study aimed to biosynthesis of silver nanoparticles (AgNPs) extracellularly using Aspergillus niger extracts and to evaluate their antibacterial activity. The biosynthesized AgNPs were characterized by UV-Vis, FT-IR, SEM, and EDX. Furthermore, antibacterial activity was evaluated against bacterial strains of Staphylococcus aureus (ATCC 6538, Gram-positive) and Escherichia coli (ATCC 8739, Gram-negative) through the well diffusion method. The results confirmed that the synthesized AgNPs were spherical and their dimensions were less than 100 nm. AgNPs revealed a good antibacterial activity (for 20 μg/ml) against E. coli and exhibited an excellent synergistic effect against S. aureus when combined with vancomycin. The current research had concluded that AgNPs have the potential to be an alternative or partner to antibiotics to control microbial infections caused by multidrug-resistant (MDR) pathogens. 

DOI

10.21608/bfsa.2022.239584

Keywords

Biosynthesis, Silver nanoparticle, Aspergillus niger, Antibacterial activity

Authors

First Name

Tariq

Last Name

Ahmad

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Baath University, Homs, Syria

Email

ph.tariqahmad@gmail.com

City

-

Orcid

-

First Name

Walid

Last Name

Khaddam

MiddleName

-

Affiliation

Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Baath University, Homs, Syria

Email

waleedkhaddam@gmail.com

City

-

Orcid

-

First Name

Lina

Last Name

Alnaddaf

MiddleName

-

Affiliation

Department of Field Crops, Faculty of Agriculture, Al-Baath University, Homs, Syria

Email

hatem005@gmail.com

City

-

Orcid

0000-0002-7251-6394

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-12-06

Publish Date

2022-06-01

Page Start

427

Page End

436

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 427-436.pdf

PDF . 901.1kB

Link

https://bpsa.journals.ekb.eg/article_239584.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239584

Order

36

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASPERGILLUS NIGER AS A BIO-LAB FOR EXTRACELLULAR SYNTHESIS OF SILVER NANOPARTICLES AND ITS ANTIBACTERIAL ACTIVITY

Details

Type

Article

Created At

22 Jan 2023