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239582

ALTERATIONS IN NEUTROPHIL-LYMPHOCYTE RATIO AND C-REACTIVE PROTEIN IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS ADMITTED TO HOSPITAL WITH AN ACUTE EXACERBATION

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Last updated: 25 Dec 2024

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Abstract

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a major cause for hospital admission and COPD(chronic obstructive pulmonary disease) related morbidity. This encouraged clinicians to search for useful and easy inflammatory biomarkers for recognizing AECOPD. Objective: To evaluate the role of the neutrophil/lymphocyte ratio (NLR) and C-reactive protein (CRP) in COPD patients for recognition of an acute exacerbation requiring hospital admission.Patients and Methods: A prospective study included 100 hospitalized AECOPD patients, 88 stable COPD, and 80 sex and age matched healthy subjects. NLR and CRP were measured twice for each patient, first at hospital admission and the second was 3 months later as follow up. NLR was calculated from the complete blood count (CBC).Results: The total white blood cell count (WBCs), Neutrophils, and NLR ratio were significantly higher in AECOPD group (P< 0.05 for each). CRP and forced expiratory volume in first second (FEV1% predicted) showed a significant correlation with NLR (P˂ 0.05). At cut off value˃ 3.26 for NLR the sensitivity and specificity were 84.7% and 78.0% respectively, whileat cut off value> 4.11 for CRP the sensitivity and specificity were 77.9 % and 68.2% respectively for the prediction of AECOPD. Conclusion: Elevated NLR can be used as a marker similar to WBCs and CRP, in the detection of increased inflammation in hospitalized acutely exacerbated COPD patients.

DOI

10.21608/bfsa.2022.239582

Keywords

acute exacerbations of COPD, Neutrophil/lymphocyte ratio, Hospitalization, CRP

Authors

First Name

Manal

Last Name

Mahmoud

MiddleName

A.

Affiliation

Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assiut University, 71515, Egypt. Tel: 088 2413717, Fax: 088 2332278

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Orcid

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First Name

Aliae

Last Name

Hussien

MiddleName

AR. Mohamed

Affiliation

Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assiut University, 71515, Egypt. Tel: 088 2413717, Fax: 088 2332278

Email

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City

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Orcid

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First Name

Hoda

Last Name

Makhlouf

MiddleName

A.

Affiliation

Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assiut University, 71515, Egypt. Tel: 088 2413717, Fax: 088 2332278

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-11-28

Publish Date

2022-06-01

Page Start

411

Page End

417

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 411-417.pdf

PDF . 717.2kB

Link

https://bpsa.journals.ekb.eg/article_239582.html

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https://bpsa.journals.ekb.eg/service?article_code=239582

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34

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ALTERATIONS IN NEUTROPHIL-LYMPHOCYTE RATIO AND C-REACTIVE PROTEIN IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS ADMITTED TO HOSPITAL WITH AN ACUTE EXACERBATION

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Article

Created At

22 Jan 2023