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239581

T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY

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Last updated: 25 Dec 2024

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder distinguished by the presence of autoantibodies causing multiorgan damages. Follicular regulatory T (Tfr) cells are mainly located in germinal centers (GCs) and play vital role in inducing Tfh suppression, sustaining B cell tolerance and inhibiting autoantibodies development. Dysregulated Tfr cells result in abnormal GCs responses and contribute to the pathogenesis of autoimmune diseases. However, the exact role of Tfr cells in SLE is still ambiguous. The present review focuses on the immunological bases and the disturbed balance of Tfr and Tfh cells in autoimmune diseases, particularly SLE. In addition to the new therapeutic strategies for SLE.

DOI

10.21608/bfsa.2022.239581

Keywords

SLE, autoimmune diseases, innate immunity, Tfr, Tfh

Authors

First Name

Yasmien

Last Name

Abdel-moneam

MiddleName

H.

Affiliation

Department of Microbiology & Immunology, Faculty of Pharmacy, Assuit University, Assuit, Egypt

Email

yasmienhussien248@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdel-Rahim

MiddleName

H.

Affiliation

Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

mona.hussein@aun.edu.eg

City

-

Orcid

-

First Name

Helal

Last Name

Hetta

MiddleName

F.

Affiliation

Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

helalhetta@yahoo.com

City

-

Orcid

0000-0001-8541-7304

First Name

Omar

Last Name

Herdan

MiddleName

M.

Affiliation

Department of Internal Medicine, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

herdan4@aun.edu.eg

City

-

Orcid

-

First Name

Khalid

Last Name

Hassanein

MiddleName

M.

Affiliation

Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

-

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-11-11

Publish Date

2022-06-01

Page Start

401

Page End

409

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 401-409.pdf

PDF . 649.5kB

Link

https://bpsa.journals.ekb.eg/article_239581.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239581

Order

33

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY

Details

Type

Article

Created At

22 Jan 2023