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239580

AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA

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Last updated: 25 Dec 2024

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Abstract

During pregnancy, the key determinant to pregnancy success is the response of the maternal immune system towards the semi-allogeneic fetus. The pregnant uterus produces numerous cytokines such as interleukin (IL)-10 and transforming growth factor-beta (TGF-β) that are of critical importance from an immune perspective due to their immunosuppressive properties. Specific B cells can have a regulatory function in addition to their humoral activity. Pre-eclampsia (PE) is a syndrome that arises in 4%–8% of pregnancies and defined as new-onset proteinuria and hypertension after 20 weeks gestation. PE is characterized by maternal endothelial dysfunction caused by circulating fetal-derived factors from the placenta. The American College of Obstetricians and Gynecologists (ACOG) 2020 described the diagnostic criteria of PE as elevated systolic blood pressure to 140 mm Hg or higher or elevated diastolic blood pressure to 90 mm Hg or higher measured at least 4 hours apart on two occasions after 20 weeks of gestation in a formerly normotensive woman. In the pathophysiology of PE, B cells are a major player. A number of studies have linked abnormal B cell numbers and functions to obstetric problems.

DOI

10.21608/bfsa.2022.239580

Keywords

Normal pregnancy, preeclampsia (PE), B cell subsets

Authors

First Name

Wegdan

Last Name

Mohamed

MiddleName

A

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Orcid

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First Name

Alshimaa

Last Name

Abdel-Hakim

MiddleName

G.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

arwagamal30@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Zakherah

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Omnia

Last Name

El-Badawy

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Ehsan

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

dr_ehsan66@yahoo.com

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-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-10-23

Publish Date

2022-06-01

Page Start

389

Page End

399

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 389-399.pdf

PDF . 675.7kB

Link

https://bpsa.journals.ekb.eg/article_239580.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239580

Order

32

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

AN OVERVIEW OF B CELL IMMUNOMODULATORY ROLE IN NORMAL PREGNANCY AND PREECLAMPSIA

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Type

Article

Created At

22 Jan 2023