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239522

ANTI-INFLAMMATORY, ANALGESIC AND ULCEROGENIC POTENCY OF CURCUMIN IN COMPARISON WITH CELECOXIB AND PREDNISOLONE

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Last updated: 25 Dec 2024

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Abstract

The present study investigates the anti-inflammatory, analgesic effect, and gastric disturbance of curcumin compared with celecoxib and prednisolone. Sixty male rats divided into (Group 1 and G2: control, G3, G4, and G5: orally received celecoxib, prednisolone, and curcumin respectively then received carrageenan in paw after 14 days. Edema, oxidative markers, analgesic, ulcerogenic activity, skin expression of (nuclear factor kappa-β (NF-kappaβ), tumor necrosis factor-alpha (TNF-α), Interleukin-1β (IL1β), IL 6 and IL 10) and gastric mRNA expression of (Heme oxygenase-1 (HO-1), interleukin 8 (IL8),  nuclear factor erythroid 2-related factor 2 (Nrf2), NFκβ and Superoxide dismutase (SOD)) were measured. This result revealed that curcumin significantly improved edema, ulcerogenic,  analgesic activity, and oxidative markers like celecoxib and prednisolone effect when compared with carrageenan. Curcumin significantly downregulated mRNA expression of the inflammatory markers of skin and gastric mucosae like celecoxib and prednisolone effect when compared with carrageenan. Curcumin, celecoxib, and prednisolone significantly upregulated skin (IL10) compared with carrageenan. Curcumin significantly upregulated Ho-1, SOD, and Nrf2 compared with carrageenan, celecoxib, and prednisolone. Based on the above it could conclude that curcumin displayed anti-inflammatory and analgesic with minimum gastric disturbance, unlike celecoxib and prednisolone.

DOI

10.21608/bfsa.2022.239522

Keywords

Carrageenan, Celecoxib, Curcumin, Inflammation, oxidative stress and Prednisolone

Authors

First Name

Saydat

Last Name

Abd-El Megid

MiddleName

S.

Affiliation

Biochemistry Department Faculty of Veterinary Medicine, Zagazig University, Egypt

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Orcid

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First Name

Tarek

Last Name

Khamis

MiddleName

-

Affiliation

Departments of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt/ Laboratories of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt

Email

tarekkhamis13@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Arisha

MiddleName

H.

Affiliation

Department of Animal Physiology and Biochemistry, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Badr City, Cairo, Egypt/ Departments of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt

Email

-

City

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Orcid

-

First Name

Eman

Last Name

Abd-El Rahman

MiddleName

O.

Affiliation

Bachelor of pharmacy, Zagazig University ,Egypt

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City

-

Orcid

-

First Name

Doaa

Last Name

Abd-El Fattah

MiddleName

M.

Affiliation

Biochemistry Department Faculty of Veterinary Medicine, Zagazig University, Egypt

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-

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-

Orcid

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-09-14

Publish Date

2022-06-01

Page Start

339

Page End

350

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 339-350.pdf

PDF . 1.3MB

Link

https://bpsa.journals.ekb.eg/article_239522.html

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https://bpsa.journals.ekb.eg/service?article_code=239522

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28

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTI-INFLAMMATORY, ANALGESIC AND ULCEROGENIC POTENCY OF CURCUMIN IN COMPARISON WITH CELECOXIB AND PREDNISOLONE

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Article

Created At

22 Jan 2023