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239446

ASSESSING THE QUANTITY AND QUALITY OF OZONATED OLIVE OIL AND STUDYING ITS SHELF-LIFE STABILITY

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Last updated: 25 Dec 2024

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Abstract

Ozonated oils have received an increasing interest lately due to the importance of their  products in medicine. Therefore, Quantitative and qualitative analysis of ozonated olive oil was applied, and its shelf-life stability study was also performed to ascertain its effectiveness. For qualitative determination, physical tests (density and viscosity), as well as 1H-NMR spectroscopy were applied. For quantitative determination, Ozone Efficiency method was used, after it was validated, throughout peroxide value. Ozone Efficiency method was basically used as a new method for monitoring the stability of the ozonated olive oil, and it was supported by Acidity Value method. Ozone Efficiency method was evaluated for linearity, accuracy, and precision according to ICH guidelines. Validation results showed that Ozone Efficiency method gave accepted linearity (R2= 0.9984), with excellent mean recovery values (98-102%), and precision with RSD% < 2%. Shelf-life stability study was conducted for six months, with storage temperature control. For stability study results, it was noticed that Ozone Efficiency and Peroxide values decreased while Acidity values increased. These changes were faster at higher temperature. Therefore, the temperature of storage should be lower, and appropriate excipients should be studied to be added to the ozonated olive oil. In addition, the results showed that Ozone Efficiency method is better and more effective than Acidity Value method in monitoring the stability of the ozonated oil.

DOI

10.21608/bfsa.2022.239446

Keywords

1H-NMR, Ozone Efficiency, peroxide value, Ozonated olive oil, Shelf-life Stability

Authors

First Name

Sarab

Last Name

Jbara

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

sarab2jbara@gmail.com

City

-

Orcid

-

First Name

Ahmad

Last Name

Shehadeh

MiddleName

Safwan

Affiliation

Orthopedic Surgery, Faculty of Medicine, University of Damascus, Aleppo, Syria

Email

-

City

-

Orcid

-

First Name

Saleh

Last Name

Trefi

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

trefiquality@gmail.com

City

-

Orcid

-

First Name

Yaser

Last Name

Bitar

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry and Quality control, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Email

dr.ybitar@hotmail.com

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-11-14

Publish Date

2022-06-01

Page Start

249

Page End

268

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 249-268.pdf

PDF . 2.2MB

Link

https://bpsa.journals.ekb.eg/article_239446.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239446

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20

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSESSING THE QUANTITY AND QUALITY OF OZONATED OLIVE OIL AND STUDYING ITS SHELF-LIFE STABILITY

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Article

Created At

22 Jan 2023