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239369

NEUROPHARMACOLOGICAL ACTIVITIES OF METHANOLIC EXTRACT OF LEAVES OF VISCUM CAPITELLATUM SMITH.

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Last updated: 04 Jan 2025

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Abstract

In present study, Viscum capitellatum Sm., hyperparasite was investigated for various neuropharmacological activities such as locomotor activity, skeletal muscle relaxation activity, antianxiety and sleep potentiation using Swiss Albino mice. The effects of methanol extract of V. capitellatum (MEVC)on anxiety, depression, rota rod performance and pentobarbital-induced sleep time were evaluated. The anxiolytic activity of MEVC at lower dose (100 mg/kg) was characterized by increased time spent and number of entries in open arms in the elevated plus maze paradigm as compared to control group. The MEVC (100, 200, and 400 mg/kg, i.p.) showed dose-dependent significant increase in motor coordination in rota rod performance test. The MEVC at the doses 500 mg/kg, i.p. was found to produce a significant prolongation of pentobarbital-induced sleeping time. The phytochemical estimation revealed the presence of significantly high amount of polyphenols. The results of the study showed that the V. capitellatum possesses neuropharmacological activity, confirming the traditional claims.

DOI

10.21608/bfsa.2022.239369

Keywords

Viscum capitellatum, neuropharmacology, Hyperparasitic plants, Polyphenols

Authors

First Name

Varsha

Last Name

Jadhav

MiddleName

S.

Affiliation

Department of Pharmacognosy, MES College of Pharmacy, Sonai, Ahmednagar, India

Email

varsha_2131@rediffmail.com

City

-

Orcid

-

First Name

Vilas

Last Name

Ghawate

MiddleName

B.

Affiliation

Department of Pharmacognosy, MES College of Pharmacy, Sonai, Ahmednagar, India

Email

vbghawate@gmail.com

City

-

Orcid

-

First Name

Ramchandra

Last Name

Jadhav

MiddleName

B.

Affiliation

Department of Pharmacognosy, SVPM'S College of Pharmacy, Malegaon(BK), Pune, India

Email

ramjadhav123@gmail.com

City

-

Orcid

-

First Name

Sanjay

Last Name

Surana

MiddleName

J.

Affiliation

Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule India

Email

sjsurana@yahoo.com

City

-

Orcid

-

First Name

Mohan

Last Name

Kalaskar

MiddleName

G.

Affiliation

Department of Pharmacognosy, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule India

Email

kalaskar.mohan@gmail.com

City

-

Orcid

0000-0002-3123-4753

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-11-11

Publish Date

2022-06-01

Page Start

129

Page End

137

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 129-137.pdf

PDF . 935.8kB

Link

https://bpsa.journals.ekb.eg/article_239369.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239369

Order

11

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NEUROPHARMACOLOGICAL ACTIVITIES OF METHANOLIC EXTRACT OF LEAVES OF VISCUM CAPITELLATUM SMITH.

Details

Type

Article

Created At

22 Jan 2023