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239367

COMPARISON OF THE EFFECT OF SALVIA OFFICINALIS EXTRACT AND VITEX AGNUS-CASTUS EXTRACT ON ANXIETY IN POSTMENOPAUSAL WOMEN: A RANDOMIZED, TRIPLE-BLIND, PLACEBO-CONTROLLED TRIAL

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Last updated: 04 Jan 2025

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Abstract

Background: This study aimed to determine the effect of Salvia officinalis extract and Vitex agnus-castus extract on anxiety in postmenopausal women. Methods: This study was a triple-blind randomized controlled clinical trial on 99 eligible postmenopausal women in Shiraz, Iran. Sampling was done using at the beginning convenience sampling from among women referring to the clinic of Namazi Hospital in Shiraz, Iran, and then permuted block randomization was used to assign patients into three groups in a 1:1:1 ratio, who were divided into 3 groups (2 intervention groups and 1 control group). Data collection tools were a demographic questionnaire and the Spielberger's State-Trait Anxiety Inventory (STAI) questionnaire. The first intervention group received Agnogel tablets (3.2-1.8 mg) once daily, the second group received Salvigol tablets (100 mg) and the third group received placebo (100 mg starch) 3 times a day for 12 weeks. STAI was again completed by the subjects after 3 months. Data were analyzed by SPSS-18 using ANOVA and paired t-test at a significance level of 0.05. Results: Mean anxiety scores before and after the intervention were 83.3 ± 24.3 and 27.5 ± 12.7 in the Agnogol group; 84.1 ± 27.8 and 26.8 ± 7.4 in the Salvigol group; and 86.3 ± 32.1 and 34.8 ± 14.1 in the control group, respectively. Based on the results of paired t-test, the decrease in mean anxiety scores in the Salvigol and Agnogel groups were significant (P< 0.001).Conclusion: The present study showed that Salvia officinalis extract and Vitex agnus-castus extract may have a good effect on relieving anxiety, so they can be used as a low-cost method with no side effects to reduce anxiety and hypochondriasis in postmenopausal women.

DOI

10.21608/bfsa.2022.239367

Keywords

Salvia officinalis, Vitex agnus-castus, Women, Menopause

Authors

First Name

Afsaneh

Last Name

Zeidabadi

MiddleName

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Affiliation

M.Sc. of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Email

afsaneeidabad@yahoo.com

City

-

Orcid

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First Name

Masoumeh

Last Name

Emamghoreishi

MiddleName

-

Affiliation

Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Email

masoumemamghoreish@gmail.com

City

-

Orcid

-

First Name

Naeimeh

Last Name

Tayebi

MiddleName

-

Affiliation

Department of Midwifery, School of Nursing and Midwifery, Bam University of Medical Sciences, Bam, Iran

Email

-

City

-

Orcid

-

First Name

Marzieh

Last Name

Akbarzadeh

MiddleName

-

Affiliation

Maternal –fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Email

marzieh.akhbar@gmail.com

City

-

Orcid

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-10-17

Publish Date

2022-06-01

Page Start

119

Page End

128

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 119-128.pdf

PDF . 813.9kB

Link

https://bpsa.journals.ekb.eg/article_239367.html

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https://bpsa.journals.ekb.eg/service?article_code=239367

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COMPARISON OF THE EFFECT OF SALVIA OFFICINALIS EXTRACT AND VITEX AGNUS-CASTUS EXTRACT ON ANXIETY IN POSTMENOPAUSAL WOMEN: A RANDOMIZED, TRIPLE-BLIND, PLACEBO-CONTROLLED TRIAL

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Article

Created At

22 Jan 2023