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239211

UNRAVELLING THE ANTIOXIDANT AND ANTI-CANCEROUS PROPERTIES OF THE CHEMICAL CONSTITUENTS PRESENT IN METHANOL EXTRACT OF GREEN ALGAE CHAETOMORPHA ANTENNINA

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Last updated: 25 Dec 2024

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Abstract

Background: Chaetomorpha antennina is a green seaweed with numerous pharmacological properties such as antimicrobial, antimalarial, anti-tumour and antioxidant properties. Thus, it is essential to perform preliminary studies to identify the chemical composition of seaweed extracts and explore the phytoconstituent responsible for pharmacological activities. Cancer is the leading cause of death worldwide. The discovery of novel therapeutic mediators for the treatment of cancer is the main task. Since efficient drug delivery is possible through nanotechnology, biosynthesis of silver nanoparticles was done, followed by molecular docking studies to investigate the anti-cancer activity of seaweed extract.Methods: Phytochemical analysis of extracts of Chaetomorpha antennina was performed, followed by biosynthesis of silver nanoparticles using these algal extracts. Characterization of silver nanoparticles was done by Scanning Electron Microscopy and X-ray Diffraction. Agar-well diffusion method and 2,2-diphenyl-1- picrylhydrazyl (DPPH) assay were used to determine the antibacterial potential and antioxidant potential of algal extracts. Further, the chemical composition of the extract was distinguished by Gas chromatography-mass spectrometry.Results: Seaweed extracts possessed numerous phytochemicals and methanol extract showed the best antibacterial and antioxidant activity. Docking studies exposed the occurrence of Carpesterol dehydrate and triazines as an anti-cancer component of Chaetomorpha antennina. Conclusion: It can be concluded that seaweed is enriched with chemical constituents possessing high antioxidant activity and therefore, can serve as a promising antioxidant and anti-cancer agent

DOI

10.21608/bfsa.2022.239211

Keywords

Antibacterial, BRCA1, breast cancer, docking, GC-MS analysis

Authors

First Name

Akanksha

Last Name

Dubey

MiddleName

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Affiliation

Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore-632 014, Tamil Nadu, India

Email

dubeyakanksha3004@gmail.com

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Orcid

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First Name

Jayanthi

Last Name

Sivaraman

MiddleName

-

Affiliation

Associate Professor, Computational Drug Design Lab,Department of Biotechnology,School of Biosciences and Technology,Vellore Institute of Technology, Vellore 632014,Tamil Nadu, India

Email

jayanthi.s@vit.ac.in

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-09-08

Publish Date

2022-06-01

Page Start

75

Page End

87

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 75-87.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_239211.html

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https://bpsa.journals.ekb.eg/service?article_code=239211

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7

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

UNRAVELLING THE ANTIOXIDANT AND ANTI-CANCEROUS PROPERTIES OF THE CHEMICAL CONSTITUENTS PRESENT IN METHANOL EXTRACT OF GREEN ALGAE CHAETOMORPHA ANTENNINA

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Article

Created At

22 Jan 2023