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UPDATED REVIEW ON EXTRACTION, ISOLATION AND QUANTITATIVE ESTIMATION OF ERGOT ALKALOIDS

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Last updated: 04 Jan 2025

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Abstract

Ergot Alkaloids are potent α-blockers that cause direct smooth muscle contraction. They are products of fungi in the genus Claviceps. The most prominent member of this group is Claviceps purpurea (rye ergot fungus). Their common sources include Rye, bread as well as other grains. These are nitrogen derived- natural substances which are grouped under indole alkaloids. These ergot alkaloids are a diverse category of secondary metabolites that have been classified into 3 groups as Clavines, Amides of lysergic acid, Ergopeptines and Lactum ergot alkaloids based on their bond arrangement. They contaminate a large variety of cereals such as rye triticale, wheat and barley. In this present review, basic information regarding the ergots along with their chemistry, extraction, purification and isolation procedures for ergot alkaloids were focused, that helps to produce a purified crude extract that is taken for chromatographic analysis. This review also provides detailed informations on the chromatographic approaches for the ergot alkaloids estimations such as TLC, HPLC, HPTLC, UPLC /UHPLC, LCMS, GCMS with different detection techniques like Mass spectrometry and Fluorescence detection which was done in the past decade and also provides information regarding the pharmacological activity of ergot alkaloids like its application in the treatment of severe, throbbing headaches such as migraine, cluster headaches and also other therapeutic applications.

DOI

10.21608/bfsa.2022.239196

Keywords

Ergot alkaloids, secondary metabolites, Migraine, chromatographic approaches, Ultra Performance Liquid Chromatography

Authors

First Name

I.

Last Name

Theja

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Affiliation

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, 517502, Andhra Pradesh, India

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First Name

P.

Last Name

Sowmya

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Affiliation

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, 517502, Andhra Pradesh, India

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First Name

B.

Last Name

Ramya Kuber

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Affiliation

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, 517502, Andhra Pradesh, India

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-08-22

Publish Date

2022-06-01

Page Start

63

Page End

74

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 63-74.pdf

PDF . 1.1MB

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https://bpsa.journals.ekb.eg/article_239196.html

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https://bpsa.journals.ekb.eg/service?article_code=239196

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

UPDATED REVIEW ON EXTRACTION, ISOLATION AND QUANTITATIVE ESTIMATION OF ERGOT ALKALOIDS

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Article

Created At

22 Jan 2023