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239176

CHITOSAN BASED POLYELECTROLYTE COMPLEX NANOPARTICLES: PREPARATION AND CHARACTERIZATION

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Last updated: 25 Dec 2024

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Abstract

Recently, the use of biodegradable polymers for specialized applications such as controlled release of drug formulations gained considerable attention. Biodegradable nanoparticles have been widely utilized in drug delivery systems. In this work polyelectrolyte complexation was used to prepare chitosan nanoparticles. The preparation process and major parameters were discussed and optimized. The nanoparticles were prepared by the polyelectrolyte complexation of chitosan (CS) with hyaluronate (HA). Studies were performed to identify effect of chitosan and hyaluronate molecular weight, chitosan: hyaluronate mass ratio and the effects of the aqueous chitosan solution pH on the particle size of nanoparticles. Nanoparticles were characterized by particle size analysis, polydispersity index, zeta potential and transmission electron microscope (TEM). Results showed that nanoparticles could be prepared only within an optimal zone of appropriate chitosan and hyaluronate molecular weights and CS:HA mass ratio.  Increasing the hyaluronate molecular weight from low to high led to a significant enlargement in the particle size of the prepared nanoparticles with different chitosan molecular weights. Besides, we found that increasing the hyaluronate content at mass ratio 1:2 of CS:HA led to precipitation of nanoparticles . The particle sizes of the chitosan/HA nanoparticles significantly decreased with the increase of chitosan solution pH. The spherical shaped chitosan/HA nanoparticles were confirmed by TEM. The study showed that systematic design and modulation of the particle size of chitosan/HA polyelectrolyte complexes can be readily achieved with right control of critical processing parameters.

DOI

10.21608/bfsa.2022.239176

Keywords

Hyaluronate, Chitosan, Polyelectrolyte complex nanoparticles

Authors

First Name

Khaled

Last Name

Abuelella

MiddleName

E.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza 12585, Egypt

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City

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Orcid

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First Name

Hend

Last Name

Abd-Allah

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Email

hend.abdallah@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Sara

Last Name

Soliman

MiddleName

M.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza 12585, Egypt

Email

sara.soliman@o6u.edu.eg

City

-

Orcid

0000-0003-3143-5894

First Name

Mona

Last Name

Abdel-Mottaleb

MiddleName

M. A.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

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-

City

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Orcid

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Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2022-01-11

Publish Date

2022-06-01

Page Start

53

Page End

62

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 53-62.pdf

PDF . 633.6kB

Link

https://bpsa.journals.ekb.eg/article_239176.html

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https://bpsa.journals.ekb.eg/service?article_code=239176

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CHITOSAN BASED POLYELECTROLYTE COMPLEX NANOPARTICLES: PREPARATION AND CHARACTERIZATION

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Article

Created At

22 Jan 2023